Version 5.4
Homo sapiens Gene: DHX35
Summary
InnateDB Gene IDBG-75013.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol DHX35
Gene Name DEAH (Asp-Glu-Ala-His) box polypeptide 35
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000101452
Encoded Proteins
IDBP-75015
DEAH (Asp-Glu-Ala-His) box polypeptide 35
IDBP-75017
DEAH (Asp-Glu-Ala-His) box polypeptide 35
IDBP-75019
DEAH (Asp-Glu-Ala-His) box polypeptide 35
IDBP-375198
DEAH (Asp-Glu-Ala-His) box polypeptide 35
IDBP-594500
DEAH (Asp-Glu-Ala-His) box polypeptide 35
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary DEAD box proteins characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of the DEAD box protein family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. The function of this gene product which is a member of this family, has not been determined. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jun 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 20:38962299-39039723
Strand Forward strand
Band q11.23
Transcripts
ENST00000252011 ENSP00000252011
ENST00000373325 ENSP00000362422
ENST00000373323 ENSP00000362420
ENST00000449559 ENSP00000397997
ENST00000484417 ENSP00000432603
ENST00000493450
ENST00000482619
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
Experimentally validated
Total 3 [view]
Protein-Protein 2 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003676 nucleic acid binding
GO:0004386 helicase activity
GO:0005524 ATP binding
GO:0008026 ATP-dependent helicase activity
Biological Process
GO:0000398 mRNA splicing, via spliceosome
GO:0006200 ATP catabolic process
Cellular Component
GO:0071013 catalytic step 2 spliceosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000027655
View Gene Order
ENSBTAG00000004039
Not yet available
Cross-References
SwissProt Q9H5Z1
TrEMBL F2Z2Z2 Q5THQ7 Q5THQ9 Q5THR1
UniProt Splice Variant
Entrez Gene 60625
UniGene Hs.444520
RefSeq NM_001190809 NM_021931 XM_006723848
HUGO HGNC:15861
OMIM
CCDS CCDS13310 CCDS54463
HPRD
IMGT
EMBL AK025541 AK026412 AK303396 AL023803 BC132669 CH471077
GenPept AAI32670 BAB15166 BAB15476 BAG64452 CAI22035 EAW76006
RNA Seq Atlas 60625

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca