Version 5.4
Homo sapiens Gene: KDELR3
Summary
InnateDB Gene IDBG-7523.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol KDELR3
Gene Name KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 3
Synonyms ERD2L3
Species Homo sapiens
Ensembl Gene ENSG00000100196
Encoded Proteins
IDBP-7525
KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 3
IDBP-293597
KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 3
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Retention of resident soluble proteins in the lumen of the endoplasmic reticulum (ER) is achieved in both yeast and animal cells by their continual retrieval from the cis-Golgi, or a pre-Golgi compartment. Sorting of these proteins is dependent on a C-terminal tetrapeptide signal, usually lys-asp-glu-leu (KDEL) in animal cells, and his-asp-glu-leu (HDEL) in S. cerevisiae. This process is mediated by a receptor that recognizes, and binds the tetrapeptide-containing protein, and returns it to the ER. In yeast, the sorting receptor encoded by a single gene, ERD2, is a seven-transmembrane protein. Unlike yeast, several human homologs of the ERD2 gene, constituting the KDEL receptor gene family, have been described. KDELR3 was the third member of the family to be identified, and it encodes a protein highly homologous to KDELR1 and KDELR2 proteins. Two transcript variants of KDELR3 that arise by alternative splicing, and encode different isoforms of KDELR3 receptor, have been described. [provided by RefSeq, Jul 2008]
This gene encodes a member of the KDEL endoplasmic reticulum protein retention receptor family. Retention of resident soluble proteins in the lumen of the endoplasmic reticulum (ER) is achieved in both yeast and animal cells by their continual retrieval from the cis-Golgi, or a pre-Golgi compartment. Sorting of these proteins is dependent on a C-terminal tetrapeptide signal, usually lys-asp-glu-leu (KDEL) in animal cells, and his-asp-glu-leu (HDEL) in S. cerevisiae. This process is mediated by a receptor that recognizes, and binds the tetrapeptide-containing protein, and returns it to the ER. In yeast, the sorting receptor encoded by a single gene, ERD2, is a seven-transmembrane protein. Unlike yeast, several human homologs of the ERD2 gene, constituting the KDEL receptor gene family, have been described. KDELR3 was the third member of the family to be identified. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]
Gene Information
Type Protein coding
Genomic Location Chromosome 22:38468062-38483447
Strand Forward strand
Band q13.1
Transcripts
ENST00000216014 ENSP00000216014
ENST00000409006 ENSP00000386918
ENST00000471268
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0046923 ER retention sequence binding
Biological Process
GO:0006621 protein retention in ER lumen
GO:0006987 activation of signaling protein activity involved in unfolded protein response
GO:0015031 protein transport
GO:0016192 vesicle-mediated transport
GO:0022900 electron transport chain
GO:0030968 endoplasmic reticulum unfolded protein response
GO:0044267 cellular protein metabolic process
Cellular Component
GO:0005789 endoplasmic reticulum membrane
GO:0016021 integral component of membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000010830
View Gene Order
ENSBTAG00000009886
Not yet available
Pathways
NETPATH
REACTOME
REACT_18273
XBP1(S) activates chaperone genes pathway
REACT_18368
IRE1alpha activates chaperones pathway
REACT_18356
Unfolded Protein Response (UPR) pathway
REACT_17015
Metabolism of proteins pathway
KEGG
hsa05110
Vibrio cholerae infection pathway
INOH
PID NCI
Cross-References
SwissProt O43731
TrEMBL A0A024R1R0
UniProt Splice Variant
Entrez Gene 11015
UniGene Hs.528305
RefSeq NM_006855 NM_016657
HUGO HGNC:6306
OMIM
CCDS CCDS13972 CCDS46705
HPRD
IMGT
EMBL AK222930 AK223238 AK292102 AL035081 AL035082 BC001277 BC096722 BC098131 BC098156 BC098336 CH471095 CR456509 Z97056
GenPept AAH01277 AAH96722 AAH98131 AAH98156 AAH98336 BAD96650 BAD96958 BAF84791 CAA22673 CAA22674 CAG30395 CAX15124 EAW60237 EAW60238 EAW60240
RNA Seq Atlas 11015

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca