InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: KDELR3

Summary

InnateDB Protein

IDBP-293597.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

KDELR3

Protein Name

KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 3

Synonyms

ERD2L3;

Species

Homo sapiens

Ensembl Protein

ENSP00000386918

InnateDB Gene

IDBG-7523 (KDELR3)

Protein Structure

UniProt Annotation

Function

Required for the retention of luminal endoplasmic reticulum proteins. Determines the specificity of the luminal ER protein retention system. Also required for normal vesicular traffic through the Golgi. This receptor recognizes K-D-E-L (By similarity). {ECO:0000250}.

Subcellular Localization

Endoplasmic reticulum membrane; Multi-pass membrane protein.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0046923	ER retention sequence binding

Biological Process

GO:0006621	protein retention in ER lumen
GO:0006987	activation of signaling protein activity involved in unfolded protein response
GO:0015031	protein transport
GO:0016192	vesicle-mediated transport
GO:0022900	electron transport chain
GO:0030968	endoplasmic reticulum unfolded protein response
GO:0044267	cellular protein metabolic process