Version 5.4
Homo sapiens Gene: SPA17
Summary
InnateDB Gene IDBG-75245.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SPA17
Gene Name sperm autoantigenic protein 17
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000064199
Encoded Proteins
IDBP-75247
sperm autoantigenic protein 17
IDBP-589734
sperm autoantigenic protein 17
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a protein present at the cell surface. The N-terminus has sequence similarity to human cAMP-dependent protein kinase A (PKA) type II alpha regulatory subunit (RIIa) while the C-terminus has an IQ calmodulin-binding motif. The central portion of the protein has carbohydrate binding motifs and likely functions in cell-cell adhesion. The protein was initially characterized by its involvement in the binding of sperm to the zona pellucida of the oocyte. Recent studies indicate that it is also involved in additional cell-cell adhesion functions such as immune cell migration and metastasis. A retrotransposed pseudogene is present on chromosome 10q22.[provided by RefSeq, Jan 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome 11:124673798-124697518
Strand Forward strand
Band q24.2
Transcripts
ENST00000227135 ENSP00000227135
ENST00000532692 ENSP00000432305
ENST00000529498
ENST00000524614
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 2 [view]
Protein-Protein 2 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0003351 epithelial cilium movement
GO:0007283 spermatogenesis
GO:0007338 single fertilization
GO:0007339 binding of sperm to zona pellucida
Cellular Component
GO:0005737 cytoplasm
GO:0016020 membrane
GO:0031514 motile cilium
GO:0072372 primary cilium
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000001948
View Gene Order
ENSBTAG00000033464
Not yet available
Cross-References
SwissProt Q15506
TrEMBL
UniProt Splice Variant
Entrez Gene 53340
UniGene Hs.286233
RefSeq NM_017425
HUGO HGNC:11210
OMIM 608621
CCDS CCDS8450
HPRD
IMGT
EMBL AF334735 AF334810 AK311806 BC032457 CH471065 Z48570
GenPept AAH32457 AAK20878 AAK28125 BAG34749 CAA88459 EAW67592
RNA Seq Atlas 53340

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca