InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: SPA17

Summary

InnateDB Protein

IDBP-75247.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SPA17

Protein Name

sperm autoantigenic protein 17

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000227135

InnateDB Gene

IDBG-75245 (SPA17)

Protein Structure

UniProt Annotation

Function

Sperm surface zona pellucida binding protein. Helps to bind spermatozoa to the zona pellucida with high affinity. Might function in binding zona pellucida and carbohydrates (By similarity). {ECO:0000250}.

Subcellular Localization

Membrane {ECO:0000305}; Peripheral membrane protein {ECO:0000305}.

Disease Associations

Tissue Specificity

Testis and sperm specific.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding

Biological Process

GO:0003351	epithelial cilium movement
GO:0007283	spermatogenesis
GO:0007338	single fertilization
GO:0007339	binding of sperm to zona pellucida

Cellular Component

GO:0005737	cytoplasm
GO:0016020	membrane
GO:0031514	motile cilium
GO:0072372	primary cilium

Protein Structure and Domains

PDB ID

InterPro

IPR000048 IQ motif, EF-hand binding site
IPR003117 Dimerization-anchoring domain of cAMP-dependent protein kinase, regulatory subunit
IPR012105 Sperm surface protein Sp17
IPR027417 P-loop containing nucleoside triphosphate hydrolase

PFAM

PF00612
PF02197

PRINTS

PIRSF

PIRSF016533

SMART

SM00015
SM00394

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt