Homo sapiens Gene: SHC3

Summary
InnateDB Gene IDBG-75269.5
Last Modified 2012-02-14   [Report errors or provide feedback]
Gene Symbol SHC3
Gene Name SHC (Src homology 2 domain containing) transforming protein 3
Synonyms N-Shc; NSHC; RAI; SHCC
Species Homo sapiens
Ensembl Gene ENSG00000148082
Encoded Proteins
IDBP-75271 SHC (Src homology 2 domain containing) transforming protein 3
IDBP-75273 SHC (Src homology 2 domain containing) transforming protein 3
IDBP-75275 SHC (Src homology 2 domain containing) transforming protein 3
Entrez Gene
Summary Currently no Entrez Summary Available. You might want to check the Summary Sections of the Orthologs.
Gene Information
Type Protein coding
Genomic Location Chromosome 9: 91628060-91793682
Strand Reverse strand
Band q22.1
Transcripts
ENST00000375835  ENSP00000364995
ENST00000375831  ENSP00000364991
ENST00000375830  ENSP00000364990
Interactions
Number of Interactions   This gene and/or its encoded proteins are associated with 14 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Experimentally validated
Total 14 [view]
Protein‑Protein  12
[view]
Protein‑DNA 0
Protein‑RNA 0
DNA-DNA 2
[view]
RNA-RNA 0
DNA-RNA 0
 
Predicted by orthology
Total [view]
Gene Ontology
Accession GO Term
Molecular Function
GO:0004871 signal transducer activity
GO:0005515 protein binding
Biological Process
GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway
GO:0007173 epidermal growth factor receptor signaling pathway
GO:0007265 Ras protein signal transduction
GO:0007417 central nervous system development
GO:0007611 learning or memory
GO:0008286 insulin receptor signaling pathway
GO:0035249 synaptic transmission, glutamatergic
GO:0035556 intracellular signal transduction
GO:0048011 nerve growth factor receptor signaling pathway
Cellular Component
GO:0005575 cellular_component
GO:0005829 cytosol
Orthologs
Species
Mus musculus
Bos taurus
Gene ID Gene Order Method Confidence Comments
ENSMUSG00000021448 Ortholuge SSD Ortholog Ortholog supports species divergence
ENSBTAG00000011375 Not yet available Ortholuge SSD Ortholog Ortholog supports species divergence
Pathways
NETPATH
REACTOME
REACT_661 SHC-mediated signalling
REACT_508 Signal attenuation
REACT_12033 Signalling to RAS
KEGG
hsa05100  Bacterial invasion of epithelial cells
hsa04062  Chemokine signaling pathway
hsa05220  Chronic myeloid leukemia
hsa04012  ErbB signaling pathway
hsa04510  Focal adhesion
hsa05214  Glioma
hsa04910  Insulin signaling pathway
hsa04650  Natural killer cell mediated cytotoxicity
hsa04722  Neurotrophin signaling pathway
INOH
INOH website EGF signaling pathway
INOH website HGF signaling pathway
INOH website IGF1 signaling pathway
INOH website IL-5 signaling
INOH website Insulin receptor signaling
INOH website Integrin signaling pathway
INOH website NGF signaling pathway
INOH website PDGF signaling pathway
PID BIOCARTA
PID NCI
Cross-References
SwissProt Q92529 
TrEMBL Q5T7I8
UniProt Splice Variant
Entrez Gene 53358 
UniGene Hs.292737
RefSeq NM_016848 
HUGO 18181 
OMIM 605263
CCDS CCDS6681 
HPRD 12005
IMGT
EMBL AL160054 AL353150 BC026314 D84361
GenPept AAH26314  BAA12322  BAA12323  CAI16864  CAI16865  CAI41366 
ImmGen SHC3 (murine) 
RNA Seq Atlas 53358