Homo sapiens Gene: SHC3
Summary
InnateDB Gene IDBG-75269.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SHC3
Gene Name SHC (Src homology 2 domain containing) transforming protein 3
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000148082
Encoded Proteins
SHC (Src homology 2 domain containing) transforming protein 3
SHC (Src homology 2 domain containing) transforming protein 3
Protein Structure
Entrez Gene
Summary Currently no Entrez Summary Available. You might want to check the Summary Sections of the Orthologs.
Gene Information
Type Protein coding
Genomic Location Chromosome 9:89013145-89178767
Strand Reverse strand
Band q22.1
Transcripts
ENST00000375835 ENSP00000364995
ENST00000375831 ENSP00000364991
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 20 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Experimentally validated
Total 20 [view]
Protein-Protein 18 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 2 [view]
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 3 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004871 signal transducer activity
GO:0005515 protein binding
Biological Process
GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway
GO:0007173 epidermal growth factor receptor signaling pathway
GO:0007265 Ras protein signal transduction
GO:0007417 central nervous system development
GO:0007611 learning or memory
GO:0008286 insulin receptor signaling pathway
GO:0035249 synaptic transmission, glutamatergic
GO:0048011 neurotrophin TRK receptor signaling pathway
Cellular Component
GO:0005575 cellular_component
GO:0005829 cytosol
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
SHC-related events pathway
Signalling by NGF pathway
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) pathway
SHC-related events triggered by IGF1R pathway
Signal Transduction pathway
SHC-mediated signalling pathway
Insulin receptor signalling cascade pathway
Signalling to ERKs pathway
NGF signalling via TRKA from the plasma membrane pathway
IGF1R signaling cascade pathway
Signal attenuation pathway
Signalling to RAS pathway
Signaling by Insulin receptor pathway
KEGG
ErbB signaling pathway pathway
Chemokine signaling pathway pathway
Focal adhesion pathway
Natural killer cell mediated cytotoxicity pathway
Neurotrophin signaling pathway pathway
Insulin signaling pathway pathway
Bacterial invasion of epithelial cells pathway
Glioma pathway
Chronic myeloid leukemia pathway
INOH
IGF1 signaling pathway pathway
NGF signaling pathway pathway
PDGF signaling pathway pathway
Integrin signaling pathway pathway
IL-5 signaling pathway
Insulin receptor signaling pathway
HGF signaling pathway pathway
EGF signaling pathway pathway
PID BIOCARTA
PID NCI
Cross-References
SwissProt Q92529
TrEMBL Q5T7I8
UniProt Splice Variant
Entrez Gene 53358
UniGene Hs.292737
RefSeq NM_016848
HUGO HGNC:18181
OMIM 605263
CCDS CCDS6681
HPRD 12005
IMGT
EMBL AL160054 AL353150 BC026314 D84361
GenPept AAH26314 BAA12322 BAA12323 CAI16865 CAI41366
ImmGen SHC3 (murine)
RNA Seq Atlas 53358