InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: SHC3

Summary

InnateDB Protein

IDBP-75271.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SHC3

Protein Name

SHC (Src homology 2 domain containing) transforming protein 3

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000364995

InnateDB Gene

IDBG-75269 (SHC3)

Protein Structure

UniProt Annotation

Function

Signaling adapter that couples activated growth factor receptors to signaling pathway in neurons. Involved in the signal transduction pathways of neurotrophin-activated Trk receptors in cortical neurons.

Subcellular Localization

Disease Associations

Tissue Specificity

Mainly expressed in brain. Hardly detectable in other tissues, except in pancreas. Highly expressed in the cerebral cortex, frontal and temporal lobes, occipital pole, hippocampus, caudate nucleus and amygdala. Expressed at low level in the cerebellum, medulla and spinal cord. {ECO:0000269PubMed:8808684}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 20 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Experimentally validated
Total	20 [view]
Protein-Protein	18 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	2 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004871	signal transducer activity
GO:0005515	protein binding

Biological Process

GO:0007169	transmembrane receptor protein tyrosine kinase signaling pathway
GO:0007173	epidermal growth factor receptor signaling pathway
GO:0007265	Ras protein signal transduction
GO:0007417	central nervous system development
GO:0007611	learning or memory
GO:0008286	insulin receptor signaling pathway
GO:0035249	synaptic transmission, glutamatergic
GO:0048011	neurotrophin TRK receptor signaling pathway