Version 5.4
Homo sapiens Gene: IARS
Summary
InnateDB Gene IDBG-75850.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol IARS
Gene Name isoleucyl-tRNA synthetase
Synonyms IARS1; ILERS; ILRS; IRS; PRO0785
Species Homo sapiens
Ensembl Gene ENSG00000196305
Encoded Proteins
IDBP-75856
isoleucyl-tRNA synthetase
IDBP-75862
isoleucyl-tRNA synthetase
IDBP-239226
isoleucyl-tRNA synthetase
IDBP-375058
isoleucyl-tRNA synthetase
IDBP-375064
isoleucyl-tRNA synthetase
IDBP-375120
isoleucyl-tRNA synthetase
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Aminoacyl-tRNA synthetases catalyze the aminoacylation of tRNA by their cognate amino acid. Because of their central role in linking amino acids with nucleotide triplets contained in tRNAS, aminoacyl-tRNA synthetases are thought to be among the first proteins that appeared in evolution. Isoleucine-tRNA synthetase belongs to the class-I aminoacyl-tRNA synthetase family and has been identified as a target of autoantibodies in the autoimmune disease polymyositis/dermatomyositis. Alternatively spliced transcript variants have been found. [provided by RefSeq, Nov 2012]
Gene Information
Type Protein coding
Genomic Location Chromosome 9:92210207-92293716
Strand Reverse strand
Band q22.31
Transcripts
ENST00000375643 ENSP00000364794
ENST00000375627 ENSP00000364778
ENST00000395554 ENSP00000378922
ENST00000443024 ENSP00000406448
ENST00000447699 ENSP00000415020
ENST00000430417 ENSP00000387603
ENST00000474340
ENST00000473915
ENST00000467876
ENST00000472894
ENST00000498025
ENST00000490438
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 75 experimentally validated interaction(s) in this database.
Experimentally validated
Total 75 [view]
Protein-Protein 75 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0000166 nucleotide binding
GO:0002161 aminoacyl-tRNA editing activity
GO:0004812 aminoacyl-tRNA ligase activity
GO:0004822 isoleucine-tRNA ligase activity
GO:0005515 protein binding
GO:0005524 ATP binding
Biological Process
GO:0001649 osteoblast differentiation
GO:0006418 tRNA aminoacylation for protein translation
GO:0006428 isoleucyl-tRNA aminoacylation
GO:0006450 regulation of translational fidelity
GO:0010467 gene expression
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0016020 membrane
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000037851
View Gene Order
ENSBTAG00000000974
Not yet available
Pathways
NETPATH
REACTOME
REACT_15306
Cytosolic tRNA aminoacylation pathway
REACT_15482
tRNA Aminoacylation pathway
REACT_71
Gene Expression pathway
KEGG
hsa00970
Aminoacyl-tRNA biosynthesis pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.445403
RefSeq NM_002161 NM_013417
HUGO
OMIM
CCDS CCDS6694
HPRD 02832
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca