InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: IARS

Summary

InnateDB Protein

IDBP-375058.4

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

IARS

Protein Name

isoleucyl-tRNA synthetase

Synonyms

IARS1; ILERS; ILRS; IRS; PRO0785;

Species

Homo sapiens

Ensembl Protein

ENSP00000406448

InnateDB Gene

IDBG-75850 (IARS)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Cytoplasm {ECO:0000269PubMed:7721108}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 75 experimentally validated interaction(s) in this database.

Experimentally validated
Total	75 [view]
Protein-Protein	75 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000166	nucleotide binding
GO:0002161	aminoacyl-tRNA editing activity
GO:0004812	aminoacyl-tRNA ligase activity
GO:0004822	isoleucine-tRNA ligase activity
GO:0005515	protein binding
GO:0005524	ATP binding

Biological Process

GO:0001649	osteoblast differentiation
GO:0006418	tRNA aminoacylation for protein translation
GO:0006428	isoleucyl-tRNA aminoacylation
GO:0006450	regulation of translational fidelity
GO:0010467	gene expression

Cellular Component

GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0016020	membrane
GO:0070062	extracellular vesicular exosome

Protein Structure and Domains

PDB ID

InterPro

IPR002300 Aminoacyl-tRNA synthetase, class Ia
IPR002301 Isoleucine-tRNA ligase
IPR009008 Valyl/Leucyl/Isoleucyl-tRNA synthetase, editing domain
IPR009080 Aminoacyl-tRNA synthetase, class 1a, anticodon-binding
IPR013155 Valyl/Leucyl/Isoleucyl-tRNA synthetase, anticodon-binding
IPR015413 Methionyl/Leucyl tRNA synthetase

PFAM

PF00133
PF08264
PF09334

PRINTS

PR00984

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

P41252