Version 5.4
Homo sapiens Gene: EXOC5
Summary
InnateDB Gene IDBG-7587.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol EXOC5
Gene Name exocyst complex component 5
Synonyms HSEC10; PRO1912; SEC10; SEC10L1; SEC10P
Species Homo sapiens
Ensembl Gene ENSG00000070367
Encoded Proteins
IDBP-7589
exocyst complex component 5
IDBP-370268
exocyst complex component 5
IDBP-602578
exocyst complex component 5
IDBP-598112
exocyst complex component 5
IDBP-810195
exocyst complex component 5
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene is a component of the exocyst complex, a multiple protein complex essential for targeting exocytic vesicles to specific docking sites on the plasma membrane. Though best characterized in yeast, the component proteins and functions of exocyst complex have been demonstrated to be highly conserved in higher eukaryotes. At least eight components of the exocyst complex, including this protein, are found to interact with the actin cytoskeletal remodeling and vesicle transport machinery. The complex is also essential for the biogenesis of epithelial cell surface polarity. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 14:57200507-57269008
Strand Reverse strand
Band q22.3
Transcripts
ENST00000340918 ENSP00000342100
ENST00000413566 ENSP00000389934
ENST00000554011
ENST00000555148 ENSP00000451082
ENST00000556629
ENST00000554934
ENST00000554598
ENST00000556911
ENST00000555749
ENST00000556318 ENSP00000452084
ENST00000621441 ENSP00000484855
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 24 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 24 [view]
Protein-Protein 22 [view]
Protein-DNA 2 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0047485 protein N-terminus binding
Biological Process
GO:0006887 exocytosis
GO:0006892 post-Golgi vesicle-mediated transport
GO:0015031 protein transport
GO:0016192 vesicle-mediated transport
GO:0044267 cellular protein metabolic process
GO:0048278 vesicle docking
GO:0061024 membrane organization
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0016020 membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000061244
View Gene Order
ENSBTAG00000013042
Not yet available
Pathways
NETPATH
REACTOME
REACT_15550
Insulin processing pathway
REACT_147867
Translocation of GLUT4 to the plasma membrane pathway
REACT_17015
Metabolism of proteins pathway
REACT_160078
Peptide hormone metabolism pathway
REACT_11123
Membrane Trafficking pathway
KEGG
INOH
PID NCI
arf6_traffickingpathway
Arf6 trafficking events
insulin_pathway
Insulin Pathway
Cross-References
SwissProt O00471
TrEMBL F8W9B8 G3V377 G3V4Z7 Q658M3
UniProt Splice Variant
Entrez Gene 10640
UniGene Hs.645295 Hs.741807
RefSeq NM_006544 XM_005267272
HUGO HGNC:10696
OMIM 604469
CCDS CCDS45111
HPRD
IMGT
EMBL AK312523 AL139195 AL391152 AL833745 CH471061 U85946
GenPept AAB53388 BAG35422 CAH56255 EAW80699
RNA Seq Atlas 10640

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca