Version 5.4
Homo sapiens Gene: ARHGAP32
Summary
InnateDB Gene IDBG-76010.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ARHGAP32
Gene Name Rho GTPase activating protein 32
Synonyms GC-GAP; GRIT; p200RhoGAP; p250GAP; PX-RICS; RICS
Species Homo sapiens
Ensembl Gene ENSG00000134909
Encoded Proteins
IDBP-76012
Rho GTPase activating protein 32
IDBP-245211
Rho GTPase activating protein 32
IDBP-592914
Rho GTPase activating protein 32
IDBP-594210
Rho GTPase activating protein 32
IDBP-598732
Rho GTPase activating protein 32
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary RICS is a neuron-associated GTPase-activating protein that may regulate dendritic spine morphology and strength by modulating Rho GTPase (see RHOA; MIM 165390) activity (Okabe et al., 2003 [PubMed 12531901]).[supplied by OMIM, Mar 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 11:128965060-129279324
Strand Reverse strand
Band q24.3
Transcripts
ENST00000310343 ENSP00000310561
ENST00000392657 ENSP00000376425
ENST00000526162
ENST00000524655 ENSP00000432468
ENST00000527272 ENSP00000432862
ENST00000534357
ENST00000533509
ENST00000525234 ENSP00000432303
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 43 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.
Experimentally validated
Total 43 [view]
Protein-Protein 42 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 6 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005096 GTPase activator activity
GO:0005515 protein binding
GO:0035091 phosphatidylinositol binding
Biological Process
GO:0007165 signal transduction
GO:0007264 small GTPase mediated signal transduction
GO:0043547 positive regulation of GTPase activity
GO:0051056 regulation of small GTPase mediated signal transduction
Cellular Component
GO:0000139 Golgi membrane
GO:0005622 intracellular
GO:0005789 endoplasmic reticulum membrane
GO:0005829 cytosol
GO:0005938 cell cortex
GO:0010008 endosome membrane
GO:0014069 postsynaptic density
GO:0015629 actin cytoskeleton
GO:0030054 cell junction
GO:0043197 dendritic spine
GO:0045211 postsynaptic membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000041444
View Gene Order
ENSBTAG00000015905
Not yet available
Pathways
NETPATH
NetPath_4
EGFR1 pathway
REACTOME
REACT_11051
Rho GTPase cycle pathway
REACT_11044
Signaling by Rho GTPases pathway
REACT_111102
Signal Transduction pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.440379 Hs.594618
RefSeq NM_001142685 NM_014715 XM_005271736 XM_006718947
HUGO
OMIM
CCDS CCDS31718 CCDS44769
HPRD 12257
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca