InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: ARHGAP32

Summary

InnateDB Protein

IDBP-245211.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ARHGAP32

Protein Name

Rho GTPase activating protein 32

Synonyms

GC-GAP; GRIT; p200RhoGAP; p250GAP; PX-RICS; RICS;

Species

Homo sapiens

Ensembl Protein

ENSP00000376425

InnateDB Gene

IDBG-76010 (ARHGAP32)

Protein Structure

UniProt Annotation

Function

GTPase-activating protein (GAP) promoting GTP hydrolysis on RHOA, CDC42 and RAC1 small GTPases. May be involved in the differentiation of neuronal cells during the formation of neurite extensions. Involved in NMDA receptor activity-dependent actin reorganization in dendritic spines. May mediate cross-talks between Ras- and Rho-regulated signaling pathways in cell growth regulation. Isoform 2 has higher GAP activity (By similarity). {ECO:0000250}.

Subcellular Localization

Cell junction, synapse, postsynaptic cell membrane, postsynaptic density. Cell projection, dendritic spine {ECO:0000250}. Cytoplasm, cell cortex. Endosome membrane {ECO:0000250}. Golgi apparatus membrane {ECO:0000250}. Endoplasmic reticulum membrane {ECO:0000250}. Membrane. Note=Association to membrane via PX domain. Associated with cortical actin in undifferentiated neuroblastoma cells, but localized to dendritic spine and postsynaptic density after differentiation (By similarity). Colocalizes with EGFR at the cell membrane upon EGF treatment. Colocalizes with GAB2 at the cell membrane. {ECO:0000250}.

Disease Associations

Tissue Specificity

Isoform 1 and isoform 2 are highly expressed in brain and testis. Isoform 1 is also expressed in other tissues such as lung, liver and spleen. {ECO:0000269PubMed:12446789}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 43 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.

Experimentally validated
Total	43 [view]
Protein-Protein	42 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	6 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005096	GTPase activator activity
GO:0005515	protein binding
GO:0035091	phosphatidylinositol binding

Biological Process

GO:0007165	signal transduction
GO:0007264	small GTPase mediated signal transduction
GO:0043547	positive regulation of GTPase activity
GO:0051056	regulation of small GTPase mediated signal transduction

Cellular Component

GO:0000139	Golgi membrane
GO:0005622	intracellular
GO:0005789	endoplasmic reticulum membrane
GO:0005829	cytosol
GO:0005938	cell cortex
GO:0010008	endosome membrane
GO:0014069	postsynaptic density
GO:0030054	cell junction
GO:0043197	dendritic spine
GO:0045211	postsynaptic membrane