Version 5.4
Homo sapiens Gene: HNRNPH3
Summary
InnateDB Gene IDBG-76023.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol HNRNPH3
Gene Name heterogeneous nuclear ribonucleoprotein H3 (2H9)
Synonyms 2H9; HNRPH3
Species Homo sapiens
Ensembl Gene ENSG00000096746
Encoded Proteins
IDBP-76025
heterogeneous nuclear ribonucleoprotein H3 (2H9)
IDBP-76027
heterogeneous nuclear ribonucleoprotein H3 (2H9)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene belongs to the subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are RNA binding proteins and they complex with heterogeneous nuclear RNA (hnRNA). These proteins are associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other aspects of mRNA metabolism and transport. While all of the hnRNPs are present in the nucleus, some seem to shuttle between the nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties. The protein encoded by this gene has two repeats of quasi-RRM domains that bind to RNAs. It is localized in nuclear bodies of the nucleus. This protein is involved in the splicing process and it also participates in early heat shock-induced splicing arrest by transiently leaving the hnRNP complexes. Several alternatively spliced transcript variants have been noted for this gene, however, not all are fully characterized. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 10:68331174-68343191
Strand Forward strand
Band q21.3
Transcripts
ENST00000265866 ENSP00000265866
ENST00000354695 ENSP00000346726
ENST00000469172
ENST00000461310
ENST00000480987
ENST00000486854
ENST00000467249
ENST00000481819
ENST00000491200
ENST00000490442
ENST00000478698
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 83 experimentally validated interaction(s) in this database.
Experimentally validated
Total 83 [view]
Protein-Protein 83 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0000166 nucleotide binding
GO:0003676 nucleic acid binding
GO:0003723 RNA binding
GO:0005515 protein binding
GO:0044822 poly(A) RNA binding
Biological Process
GO:0000398 mRNA splicing, via spliceosome
GO:0006396 RNA processing
GO:0008380 RNA splicing
GO:0030855 epithelial cell differentiation
Cellular Component
GO:0005634 nucleus
GO:0005681 spliceosomal complex
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000020069
View Gene Order
ENSBTAG00000014316
Not yet available
Pathways
NETPATH
NetPath_11
TCR pathway
REACTOME
KEGG
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.643472 Hs.667283
RefSeq NM_012207 NM_021644 XM_005269748 XM_005269749 XM_006717816 XM_006717817
HUGO
OMIM
CCDS CCDS7278 CCDS7279
HPRD 03818
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca