InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: OGN

Summary

InnateDB Gene

IDBG-76146.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

OGN

Gene Name

osteoglycin

Synonyms

OG; OIF; SLRR3A

Species

Homo sapiens

Ensembl Gene

ENSG00000106809

Encoded Proteins

IDBP-76148

osteoglycin

IDBP-76150

osteoglycin

IDBP-375228

osteoglycin

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene encodes a protein which induces ectopic bone formation in conjunction with transforming growth factor beta. This protein is a small proteoglycan which contains tandem leucine-rich repeats (LRR). Alternatively spliced transcript variants that encode the same protein have been found for this gene. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 9:92383967-92404696

Strand

Reverse strand

Band

q22.31

Transcripts

ENST00000375561	ENSP00000364711
ENST00000262551	ENSP00000262551
ENST00000447356	ENSP00000396709
ENST00000468743

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.

Experimentally validated
Total	2 [view]
Protein-Protein	0
Protein-DNA	2 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0008083	growth factor activity

Biological Process

GO:0005975	carbohydrate metabolic process
GO:0018146	keratan sulfate biosynthetic process
GO:0030203	glycosaminoglycan metabolic process
GO:0042339	keratan sulfate metabolic process
GO:0042340	keratan sulfate catabolic process
GO:0044281	small molecule metabolic process
GO:0048662	negative regulation of smooth muscle cell proliferation

Cellular Component

GO:0005576	extracellular region
GO:0005578	proteinaceous extracellular matrix
GO:0005615	extracellular space
GO:0005796	Golgi lumen
GO:0031012	extracellular matrix
GO:0043202	lysosomal lumen