Version 5.4
Homo sapiens Protein: OGN
Summary
InnateDB Protein IDBP-76150.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol OGN
Protein Name osteoglycin
Synonyms OG; OIF; SLRR3A;
Species Homo sapiens
Ensembl Protein ENSP00000262551
InnateDB Gene IDBG-76146 (OGN)
Protein Structure
UniProt Annotation
Function Induces bone formation in conjunction with TGF-beta-1 or TGF-beta-2.
Subcellular Localization Secreted, extracellular space, extracellular matrix {ECO:0000250}.
Disease Associations
Tissue Specificity Bone.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
Experimentally validated
Total 2 [view]
Protein-Protein 0
Protein-DNA 2 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0008083 growth factor activity
Biological Process
GO:0005975 carbohydrate metabolic process
GO:0018146 keratan sulfate biosynthetic process
GO:0030203 glycosaminoglycan metabolic process
GO:0042339 keratan sulfate metabolic process
GO:0042340 keratan sulfate catabolic process
GO:0044281 small molecule metabolic process
GO:0048662 negative regulation of smooth muscle cell proliferation
Cellular Component
GO:0005576 extracellular region
GO:0005578 proteinaceous extracellular matrix
GO:0005615 extracellular space
GO:0005796 Golgi lumen
GO:0031012 extracellular matrix
GO:0043202 lysosomal lumen
Protein Structure and Domains
PDB ID
InterPro IPR001611 Leucine-rich repeat
IPR003591 Leucine-rich repeat, typical subtype
PFAM PF00560
PF13504
PF13855
PRINTS
PIRSF
SMART SM00369
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt P20774
PhosphoSite PhosphoSite-P20774
TrEMBL A8K0R3
UniProt Splice Variant
Entrez Gene 4969
UniGene Hs.682715
RefSeq NP_148935
HUGO HGNC:8126
OMIM 602383
CCDS CCDS6695
HPRD 03856
IMGT
EMBL AF100758 AF112465 AF192478 AF192479 AF192480 AF192481 AF192482 AF192483 AF202167 AK075521 AK289628 AL110267 AL133114 AL137848 BC037273 BC095443 CH471089 CR533516
GenPept AAD40453 AAD43022 AAF19364 AAF69109 AAH37273 AAH95443 BAF82317 BAG52162 CAB53706 CAB61417 CAG38547 CAI16694 EAW62818 EAW62819 EAW62820

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca