Version 5.4
Homo sapiens Gene: OPCML
Summary
InnateDB Gene IDBG-76356.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol OPCML
Gene Name opioid binding protein/cell adhesion molecule-like
Synonyms IGLON1; OBCAM; OPCM
Species Homo sapiens
Ensembl Gene ENSG00000183715
Encoded Proteins
IDBP-76358
opioid binding protein/cell adhesion molecule-like
IDBP-76360
opioid binding protein/cell adhesion molecule-like
IDBP-592162
opioid binding protein/cell adhesion molecule-like
IDBP-587610
opioid binding protein/cell adhesion molecule-like
IDBP-809483
opioid binding protein/cell adhesion molecule-like
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a member of the IgLON subfamily in the immunoglobulin protein superfamily. The encoded protein is localized in the plasma membrane and may have an accessory role in opioid receptor function. This gene has an ortholog in rat and bovine. The opioid binding-cell adhesion molecule encoded by the rat gene binds opioid alkaloids in the presence of acidic lipids, exhibits selectivity for mu ligands and acts as a GPI-anchored protein. Since the encoded protein is highly conserved in species during evolution, it may have a fundamental role in mammalian systems. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 11:132414977-133532519
Strand Reverse strand
Band q25
Transcripts
ENST00000374778 ENSP00000363910
ENST00000331898 ENSP00000330862
ENST00000524381 ENSP00000434750
ENST00000529038
ENST00000525412
ENST00000529019
ENST00000541867 ENSP00000445496
ENST00000612177 ENSP00000482061
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 2 [view]
Protein-Protein 2 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004985 opioid receptor activity
GO:0005515 protein binding
Biological Process
GO:0007155 cell adhesion
GO:0008038 neuron recognition
GO:0038003 opioid receptor signaling pathway
Cellular Component
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0031225 anchored component of membrane
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000062257
View Gene Order
ENSBTAG00000020769
Not yet available
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.4817
RefSeq NM_001012393 NM_002545 XM_005271574 XM_005271575 XM_005271578 XM_005271579 XM_006718846
HUGO
OMIM
CCDS CCDS31722 CCDS8492
HPRD 07198
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca