InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: OPCML

Summary

InnateDB Protein

IDBP-76360.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

OPCML

Protein Name

opioid binding protein/cell adhesion molecule-like

Synonyms

IGLON1; OBCAM; OPCM;

Species

Homo sapiens

Ensembl Protein

ENSP00000330862

InnateDB Gene

IDBG-76356 (OPCML)

Protein Structure

UniProt Annotation

Function

Binds opioids in the presence of acidic lipids; probably involved in cell contact.

Subcellular Localization

Cell membrane {ECO:0000250}; Lipid-anchor, GPI-anchor {ECO:0000250}.

Disease Associations

Ovarian cancer (OC) [MIM:167000]: The term ovarian cancer defines malignancies originating from ovarian tissue. Although many histologic types of ovarian tumors have been described, epithelial ovarian carcinoma is the most common form. Ovarian cancers are often asymptomatic and the recognized signs and symptoms, even of late-stage disease, are vague. Consequently, most patients are diagnosed with advanced disease. {ECO:0000269PubMed:12819783}. Note=Disease susceptibility is associated with variations affecting the gene represented in this entry.

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004985	opioid receptor activity
GO:0005515	protein binding

Biological Process

GO:0007155	cell adhesion
GO:0008038	neuron recognition
GO:0038003	opioid receptor signaling pathway

Cellular Component

GO:0005886	plasma membrane
GO:0005887	integral component of plasma membrane
GO:0031225	anchored component of membrane
GO:0070062	extracellular vesicular exosome

Protein Structure and Domains

PDB ID

InterPro

IPR003598 Immunoglobulin subtype 2
IPR003599 Immunoglobulin subtype
IPR007110 Immunoglobulin-like domain
IPR013098 Immunoglobulin I-set
IPR013106 Immunoglobulin V-set domain
IPR013151 Immunoglobulin

PFAM

PF07679
PF07686
PF00047

PRINTS

PIRSF

SMART

SM00408
SM00409

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q14982