InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: DNAJC10

Summary

InnateDB Gene

IDBG-76849.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

DNAJC10

Gene Name

DnaJ (Hsp40) homolog, subfamily C, member 10

Synonyms

Species

Homo sapiens

Ensembl Gene

ENSG00000077232

Encoded Proteins

IDBP-76851

DnaJ (Hsp40) homolog, subfamily C, member 10

IDBP-387903

DnaJ (Hsp40) homolog, subfamily C, member 10

IDBP-387904

DnaJ (Hsp40) homolog, subfamily C, member 10

IDBP-585772

DnaJ (Hsp40) homolog, subfamily C, member 10

IDBP-808867

DnaJ (Hsp40) homolog, subfamily C, member 10

IDBP-808870

DnaJ (Hsp40) homolog, subfamily C, member 10

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene encodes an endoplasmic reticulum co-chaperone which is part of the endoplasmic reticulum-associated degradation complex involved in recognizing and degrading misfolded proteins. The encoded protein reduces incorrect disulfide bonds in misfolded glycoproteins. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Oct 2012]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 2:182716041-182794464

Strand

Forward strand

Band

q32.1

Transcripts

ENST00000264065	ENSP00000264065
ENST00000418559	ENSP00000389483
ENST00000444005	ENSP00000400096
ENST00000491074
ENST00000469118
ENST00000494462
ENST00000459930
ENST00000537515	ENSP00000441560
ENST00000616986	ENSP00000479930
ENST00000613960	ENSP00000481044

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 26 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	26 [view]
Protein-Protein	26 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001671	ATPase activator activity
GO:0005515	protein binding
GO:0015035	protein disulfide oxidoreductase activity
GO:0015036	disulfide oxidoreductase activity
GO:0016671	oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor
GO:0030544	Hsp70 protein binding
GO:0051087	chaperone binding
GO:0051117	ATPase binding
GO:0051787	misfolded protein binding

Biological Process

GO:0001933	negative regulation of protein phosphorylation
GO:0030433	ER-associated ubiquitin-dependent protein catabolic process
GO:0032781	positive regulation of ATPase activity
GO:0034975	protein folding in endoplasmic reticulum
GO:0034976	response to endoplasmic reticulum stress
GO:0045454	cell redox homeostasis
GO:0055114	oxidation-reduction process
GO:0070059	intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress

Cellular Component

GO:0005783	endoplasmic reticulum
GO:0005788	endoplasmic reticulum lumen
GO:0016020	membrane
GO:0034663	endoplasmic reticulum chaperone complex

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000027006

View Gene Order

ENSBTAG00000008390

Not yet available

Pathways

NETPATH

REACTOME

KEGG

hsa04141

Protein processing in endoplasmic reticulum pathway

INOH

PID NCI

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Hs.598295

RefSeq

NM_001271581 NM_018981

HUGO

OMIM

CCDS

CCDS33345 CCDS74613

HPRD

09722

IMGT

EMBL

GenPept

RNA Seq Atlas