InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: DNAJC10

Summary

InnateDB Protein

IDBP-76851.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

DNAJC10

Protein Name

DnaJ (Hsp40) homolog, subfamily C, member 10

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000264065

InnateDB Gene

IDBG-76849 (DNAJC10)

Protein Structure

UniProt Annotation

Function

Endoplasmic reticulum disulfide reductase involved both in the correct folding of proteins and degradation of misfolded proteins. Required for efficient folding of proteins in the endoplasmic reticulum by catalyzing the removal of non-native disulfide bonds formed during the folding of proteins, such as LDLR. Also involved in endoplasmic reticulum-associated degradation (ERAD) by reducing incorrect disulfide bonds in misfolded glycoproteins recognized by EDEM1. Interaction with HSPA5 is required its activity, not for the disulfide reductase activity, but to facilitate the release of DNAJC10 from its substrate. Promotes apoptotic signaling pathway in response to endoplasmic reticulum stress. {ECO:0000269PubMed:12411443, ECO:0000269PubMed:18400946, ECO:0000269PubMed:19122239, ECO:0000269PubMed:23769672}.

Subcellular Localization

Endoplasmic reticulum lumen {ECO:0000255PROSITE-ProRule:PRU10138, ECO:0000269PubMed:12411443, ECO:0000269PubMed:23769672}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 26 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	26 [view]
Protein-Protein	26 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001671	ATPase activator activity
GO:0005515	protein binding
GO:0015035	protein disulfide oxidoreductase activity
GO:0015036	disulfide oxidoreductase activity
GO:0016671	oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor
GO:0030544	Hsp70 protein binding
GO:0051087	chaperone binding
GO:0051117	ATPase binding
GO:0051787	misfolded protein binding

Biological Process

GO:0001933	negative regulation of protein phosphorylation
GO:0030433	ER-associated ubiquitin-dependent protein catabolic process
GO:0032781	positive regulation of ATPase activity
GO:0034975	protein folding in endoplasmic reticulum
GO:0034976	response to endoplasmic reticulum stress
GO:0045454	cell redox homeostasis
GO:0055114	oxidation-reduction process
GO:0070059	intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress