Version 5.4
Homo sapiens Gene: FRZB
Summary
InnateDB Gene IDBG-76878.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol FRZB
Gene Name frizzled-related protein
Synonyms FRE; FRITZ; FRP-3; FRZB-1; FRZB-PEN; FRZB1; FZRB; hFIZ; OS1; SFRP3; SRFP3
Species Homo sapiens
Ensembl Gene ENSG00000162998
Encoded Proteins
IDBP-76880
frizzled-related protein
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene is a secreted protein that is involved in the regulation of bone development. Defects in this gene are a cause of female-specific osteoarthritis (OA) susceptibility. [provided by RefSeq, Apr 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 2:182833275-182867162
Strand Reverse strand
Band q32.1
Transcripts
ENST00000295113 ENSP00000295113
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 14 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 14 [view]
Protein-Protein 14 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0017147 Wnt-protein binding
GO:0030165 PDZ domain binding
GO:0042813 Wnt-activated receptor activity
Biological Process
GO:0001501 skeletal system development
GO:0001944 vasculature development
GO:0007420 brain development
GO:0008285 negative regulation of cell proliferation
GO:0008406 gonad development
GO:0010721 negative regulation of cell development
GO:0014033 neural crest cell differentiation
GO:0016055 Wnt signaling pathway
GO:0030178 negative regulation of Wnt signaling pathway
GO:0030308 negative regulation of cell growth
GO:0042472 inner ear morphogenesis
GO:0043065 positive regulation of apoptotic process
GO:0045600 positive regulation of fat cell differentiation
GO:0060029 convergent extension involved in organogenesis
GO:0060056 mammary gland involution
GO:0060429 epithelium development
GO:0061037 negative regulation of cartilage development
GO:0061053 somite development
GO:0070367 negative regulation of hepatocyte differentiation
GO:0090090 negative regulation of canonical Wnt signaling pathway
GO:0090103 cochlea morphogenesis
Cellular Component
GO:0005615 extracellular space
GO:0005737 cytoplasm
GO:0016020 membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000027004
View Gene Order
ENSBTAG00000010977
Not yet available
Pathways
NETPATH
NetPath_8
Wnt pathway
REACTOME
KEGG
INOH
INOH website
Wnt signaling pathway pathway
PID NCI
Cross-References
SwissProt Q92765
TrEMBL D9ZGF6 Q53QN4 Q53QT6
UniProt Splice Variant
Entrez Gene 2487
UniGene Hs.128453 Hs.714042
RefSeq NM_001463
HUGO HGNC:3959
OMIM 605083
CCDS CCDS2286
HPRD 07282
IMGT
EMBL AC105396 AC108514 BC027855 BT019883 CH471058 HM015594 U24163 U68057 U91903
GenPept AAB51298 AAC50736 AAC51217 AAH27855 AAV38686 AAX93117 AAY24241 ADL14515 EAX10958
RNA Seq Atlas 2487

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca