Version 5.4
Homo sapiens Gene: RLIM
Summary
InnateDB Gene IDBG-77203.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol RLIM
Gene Name ring finger protein, LIM domain interacting
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000131263
Encoded Proteins
IDBP-77205
ring finger protein, LIM domain interacting
IDBP-77207
ring finger protein, LIM domain interacting
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene is a RING-H2 zinc finger protein. It has been shown to be an E3 ubiquitin protein ligase that targets LIM domain binding 1 (LDB1/CLIM), and causes proteasome-dependent degradation of LDB1. This protein and LDB1 are co-repressors of LHX1/LIM-1, a homeodomain transcription factor. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Feb 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome X:74585217-74614617
Strand Reverse strand
Band q13.2
Transcripts
ENST00000332687 ENSP00000328059
ENST00000349225 ENSP00000253571
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 45 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated
Total 45 [view]
Protein-Protein 44 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003714 transcription corepressor activity
GO:0004842 ubiquitin-protein transferase activity
GO:0005515 protein binding
GO:0008270 zinc ion binding
GO:0016874 ligase activity
GO:0046872 metal ion binding
Biological Process
GO:0000122 negative regulation of transcription from RNA polymerase II promoter
GO:0006351 transcription, DNA-templated
GO:0006511 ubiquitin-dependent protein catabolic process
GO:0016567 protein ubiquitination
GO:0043433 negative regulation of sequence-specific DNA binding transcription factor activity
GO:0045892 negative regulation of transcription, DNA-templated
GO:0060816 random inactivation of X chromosome
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0017053 transcriptional repressor complex
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000056537
View Gene Order
ENSBTAG00000015630
Not yet available
Pathways
NETPATH
NetPath_24
TSLP pathway
REACTOME
KEGG
INOH
PID NCI
Cross-References
SwissProt Q9NVW2
TrEMBL
UniProt Splice Variant
Entrez Gene 51132
UniGene Hs.574236 Hs.601581 Hs.621362 Hs.653288
RefSeq NM_016120 NM_183353
HUGO HGNC:13429
OMIM 300379
CCDS CCDS14427
HPRD
IMGT
EMBL AF155109 AJ271670 AK001334 AL513007 BC013357 CH471104
GenPept AAD42875 AAH13357 BAA91632 CAC14228 CAI41712 EAW98639 EAW98640
RNA Seq Atlas 51132

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca