Version 5.4
Homo sapiens Gene: WFDC12
Summary
InnateDB Gene IDBG-77255.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol WFDC12
Gene Name WAP four-disulfide core domain 12
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000168703
Encoded Proteins
IDBP-77257
WAP four-disulfide core domain 12
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
PMID 25770093
WFDC12 plays a role in the regulation of lung inflammation.
Entrez Gene
Summary This gene encodes a member of the WAP-type four-disulfide core (WFDC) domain family. The WFDC domain, or WAP signature motif, contains eight cysteines forming four disulfide bonds at the core of the protein, and functions as a protease inhibitor. Most WFDC gene members are localized to chromosome 20q12-q13 in two clusters: centromeric and telomeric. This gene belongs to the centromeric cluster. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 20:45123425-45124465
Strand Reverse strand
Band q13.12
Transcripts
ENST00000372785 ENSP00000361871
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
Experimentally validated
Total 1 [view]
Protein-Protein 0
Protein-DNA 0
Protein-RNA 0
DNA-DNA 1 [view]
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004867 serine-type endopeptidase inhibitor activity
GO:0030414 peptidase inhibitor activity
Biological Process
GO:0010951 negative regulation of endopeptidase activity
GO:0042742 defense response to bacterium
GO:0045087 innate immune response (InnateDB)
Cellular Component
GO:0005576 extracellular region
Orthologs
No orthologs found for this gene
Cross-References
SwissProt Q8WWY7
TrEMBL
UniProt Splice Variant
Entrez Gene 128488
UniGene Hs.352180
RefSeq NM_080869
HUGO HGNC:16115
OMIM 609872
CCDS CCDS13343
HPRD
IMGT
EMBL AY037803 AY358678 Z93016
GenPept AAK68848 AAQ89041 CAI19817
RNA Seq Atlas 128488

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca