Version 5.4
Homo sapiens Protein: WFDC12
Summary
InnateDB Protein IDBP-77257.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol WFDC12
Protein Name WAP four-disulfide core domain 12
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000361871
InnateDB Gene IDBG-77255 (WFDC12)
Protein Structure
UniProt Annotation
Function Antibacterial protein. Putative acid-stable proteinase inhibitor.
Subcellular Localization Secreted {ECO:0000305}.
Disease Associations
Tissue Specificity Highly expressed in prostate, skin, lung and esophagus. Weakly expressed in skeletal muscle, epididymis, kidney, trachea, salivary gland, testis and seminal vesicle.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
Experimentally validated
Total 1 [view]
Protein-Protein 0
Protein-DNA 0
Protein-RNA 0
DNA-DNA 1 [view]
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004867 serine-type endopeptidase inhibitor activity
GO:0030414 peptidase inhibitor activity
Biological Process
GO:0010951 negative regulation of endopeptidase activity
GO:0042742 defense response to bacterium
GO:0045087 innate immune response (InnateDB)
Cellular Component
GO:0005576 extracellular region
Protein Structure and Domains
PDB ID
InterPro IPR008197 Whey acidic protein-type 4-disulphide core
PFAM PF00095
PRINTS PR00003
PIRSF
SMART SM00217
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q8WWY7
PhosphoSite PhosphoSite-Q8WWY7
TrEMBL
UniProt Splice Variant
Entrez Gene 128488
UniGene Hs.352180
RefSeq NP_543145
HUGO HGNC:16115
OMIM 609872
CCDS CCDS13343
HPRD 15674
IMGT
EMBL AY037803 AY358678 Z93016
GenPept AAK68848 AAQ89041 CAI19817

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca