Version 5.4
Homo sapiens Gene: PI3
Summary
InnateDB Gene IDBG-77287.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PI3
Gene Name peptidase inhibitor 3, skin-derived
Synonyms cementoin; ESI; SKALP; WAP3; WFDC14
Species Homo sapiens
Ensembl Gene ENSG00000124102
Encoded Proteins
IDBP-77289
peptidase inhibitor 3, skin-derived
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes an elastase-specific inhibitor that functions as an antimicrobial peptide against Gram-positive and Gram-negative bacteria. The protein contains a WAP-type four-disulfide core (WFDC) domain, and is thus a member of the WFDC domain family. Most WFDC gene members are localized to chromosome 20q12-q13 in two clusters: centromeric and telomeric. This gene belongs to the centromeric cluster. Expression of this gene is upgulated by bacterial lipopolysaccharides and cytokines. [provided by RefSeq, Oct 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 20:45174876-45176544
Strand Forward strand
Band q13.12
Transcripts
ENST00000243924 ENSP00000243924
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
Experimentally validated
Total 5 [view]
Protein-Protein 5 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004866 endopeptidase inhibitor activity
GO:0004867 serine-type endopeptidase inhibitor activity
GO:0030414 peptidase inhibitor activity
Biological Process
GO:0007620 copulation
GO:0010951 negative regulation of endopeptidase activity
Cellular Component
GO:0005576 extracellular region
GO:0005578 proteinaceous extracellular matrix
GO:0070062 extracellular vesicular exosome
Orthologs
No orthologs found for this gene
Cross-References
SwissProt P19957
TrEMBL
UniProt Splice Variant
Entrez Gene 5266
UniGene
RefSeq NM_002638
HUGO HGNC:8947
OMIM 182257
CCDS CCDS13344
HPRD
IMGT
EMBL AL049767 BC010952 CH471077 CR542234 D13156 L10343 S58717 Z18538
GenPept AAA36483 AAB26371 AAH10952 BAA02441 CAA79223 CAB53524 CAG47030 EAW75873 EAW75874
RNA Seq Atlas 5266

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca