InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: PI3

Summary

InnateDB Protein

IDBP-77289.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PI3

Protein Name

peptidase inhibitor 3, skin-derived

Synonyms

cementoin; ESI; SKALP; WAP3; WFDC14;

Species

Homo sapiens

Ensembl Protein

ENSP00000243924

InnateDB Gene

IDBG-77287 (PI3)

Protein Structure

UniProt Annotation

Function

Neutrophil and pancreatic elastase-specific inhibitor of skin. It may prevent elastase-mediated tissue proteolysis.

Subcellular Localization

Secreted.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.

Experimentally validated
Total	5 [view]
Protein-Protein	5 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004866	endopeptidase inhibitor activity
GO:0004867	serine-type endopeptidase inhibitor activity
GO:0030414	peptidase inhibitor activity

Biological Process

GO:0007620	copulation
GO:0010951	negative regulation of endopeptidase activity

Cellular Component

GO:0005576	extracellular region
GO:0005578	proteinaceous extracellular matrix
GO:0070062	extracellular vesicular exosome

Protein Structure and Domains

PDB ID

InterPro

IPR008197 Whey acidic protein-type 4-disulphide core
IPR019541 Trappin protein transglutaminase-binding repeat

PFAM

PF00095
PF10511

PRINTS

PR00003

PIRSF

SMART

SM00217

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

P19957

PhosphoSite

PhosphoSite-P19957

TrEMBL

UniProt Splice Variant

Entrez Gene

5266

UniGene

RefSeq

NP_002629

HUGO

HGNC:8947

OMIM

182257

CCDS

CCDS13344

HPRD

15947

IMGT

EMBL

AL049767 BC010952 CH471077 CR542234 D13156 L10343 S58717 Z18538

GenPept

AAA36483 AAB26371 AAH10952 BAA02441 CAA79223 CAB53524 CAG47030 EAW75873 EAW75874