InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: SLC40A1

Summary

InnateDB Gene

IDBG-77320.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SLC40A1

Gene Name

solute carrier family 40 (iron-regulated transporter), member 1

Synonyms

Species

Homo sapiens

Ensembl Gene

ENSG00000138449

Encoded Proteins

IDBP-77322

solute carrier family 40 (iron-regulated transporter), member 1

IDBP-387959

solute carrier family 40 (iron-regulated transporter), member 1

IDBP-387962

solute carrier family 40 (iron-regulated transporter), member 1

IDBP-387964

solute carrier family 40 (iron-regulated transporter), member 1

IDBP-387965

solute carrier family 40 (iron-regulated transporter), member 1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

The protein encoded by this gene is a cell membrane protein that may be involved in iron export from duodenal epithelial cells. Defects in this gene are a cause of hemochromatosis type 4 (HFE4). [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 2:189560579-189583758

Strand

Reverse strand

Band

q32.2

Transcripts

ENST00000261024	ENSP00000261024
ENST00000427241	ENSP00000390005
ENST00000418714
ENST00000455320	ENSP00000413549
ENST00000440626	ENSP00000396134
ENST00000427419	ENSP00000392730
ENST00000479598

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	4 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005381	iron ion transmembrane transporter activity
GO:0005515	protein binding

Biological Process

GO:0002260	lymphocyte homeostasis
GO:0003158	endothelium development
GO:0006826	iron ion transport
GO:0006879	cellular iron ion homeostasis
GO:0009653	anatomical structure morphogenesis
GO:0034395	regulation of transcription from RNA polymerase II promoter in response to iron
GO:0034755	iron ion transmembrane transport
GO:0043066	negative regulation of apoptotic process
GO:0048536	spleen development
GO:0055085	transmembrane transport
GO:0060345	spleen trabecula formation
GO:0060586	multicellular organismal iron ion homeostasis

Cellular Component

GO:0005622	intracellular
GO:0005737	cytoplasm
GO:0005771	multivesicular body
GO:0005886	plasma membrane
GO:0005887	integral component of plasma membrane
GO:0008021	synaptic vesicle
GO:0016021	integral component of membrane
GO:0016323	basolateral plasma membrane

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000025993

View Gene Order

ENSBTAG00000010498

Not yet available

Pathways

NETPATH

REACTOME

REACT_25060

Iron uptake and transport pathway

REACT_20547

Metal ion SLC transporters pathway

REACT_19305

Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds pathway

REACT_15518

Transmembrane transport of small molecules pathway

REACT_19118

SLC-mediated transmembrane transport pathway

KEGG

INOH

PID NCI

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Hs.643005 Hs.718111

RefSeq

NM_014585 XM_005246504

HUGO

OMIM

CCDS

CCDS2299

HPRD

05229

IMGT

EMBL

GenPept

RNA Seq Atlas