InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Slc40a1

Summary

InnateDB Gene

IDBG-151280.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Slc40a1

Gene Name

solute carrier family 40 (iron-regulated transporter), member 1

Synonyms

Dusg; Fpn1; IREG1; MTP; MTP1; Ol5; Pcm; Slc11a3; Slc39a1

Species

Mus musculus

Ensembl Gene

ENSMUSG00000025993

Encoded Proteins

IDBP-151282

solute carrier family 40 (iron-regulated transporter), member 1

IDBP-788561

solute carrier family 40 (iron-regulated transporter), member 1

IDBP-788562

solute carrier family 40 (iron-regulated transporter), member 1

IDBP-788563

solute carrier family 40 (iron-regulated transporter), member 1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000138449:
The protein encoded by this gene is a cell membrane protein that may be involved in iron export from duodenal epithelial cells. Defects in this gene are a cause of hemochromatosis type 4 (HFE4). [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 1:45908068-45926523

Strand

Reverse strand

Band

C1.1

Transcripts

ENSMUST00000027137	ENSMUSP00000027137
ENSMUST00000191247
ENSMUST00000188252
ENSMUST00000186822
ENSMUST00000187420	ENSMUSP00000140549
ENSMUST00000187406	ENSMUSP00000140734
ENSMUST00000186804	ENSMUSP00000140969
ENSMUST00000186755

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.

Experimentally validated
Total	5 [view]
Protein-Protein	5 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	5 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005381	iron ion transmembrane transporter activity
GO:0005515	protein binding

Biological Process

GO:0002260	lymphocyte homeostasis
GO:0003158	endothelium development
GO:0006826	iron ion transport
GO:0006879	cellular iron ion homeostasis
GO:0034395	regulation of transcription from RNA polymerase II promoter in response to iron
GO:0034755	iron ion transmembrane transport
GO:0043066	negative regulation of apoptotic process
GO:0048536	spleen development
GO:0060345	spleen trabecula formation
GO:0060586	multicellular organismal iron ion homeostasis

Cellular Component

GO:0005622	intracellular
GO:0005771	multivesicular body
GO:0005886	plasma membrane
GO:0008021	synaptic vesicle
GO:0016021	integral component of membrane
GO:0016323	basolateral plasma membrane