Version 5.4
Homo sapiens Gene: SLC35D2
Summary
InnateDB Gene IDBG-77339.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SLC35D2
Gene Name solute carrier family 35, member D2
Synonyms hfrc; HFRC1; SQV7L; UGTrel8
Species Homo sapiens
Ensembl Gene ENSG00000130958
Encoded Proteins
IDBP-77341
solute carrier family 35, member D2
IDBP-77343
solute carrier family 35, member D2
IDBP-77345
solute carrier family 35, member D2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Nucleotide sugars, which are synthesized in the cytosol or the nucleus, are high-energy donor substrates for glycosyltransferases located in the lumen of the endoplasmic reticulum and Golgi apparatus. Translocation of nucleotide sugars from the cytosol into the lumen compartment is mediated by specific nucleotide sugar transporters, such as SLC35D2 (Suda et al., 2004 [PubMed 15082721]).[supplied by OMIM, Mar 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 9:96320706-96383710
Strand Reverse strand
Band q22.32
Transcripts
ENST00000253270 ENSP00000253270
ENST00000375259 ENSP00000364408
ENST00000375257 ENSP00000364406
ENST00000490599
ENST00000482643
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0005338 nucleotide-sugar transmembrane transporter activity
Biological Process
GO:0005975 carbohydrate metabolic process
GO:0006024 glycosaminoglycan biosynthetic process
GO:0008150 biological_process
GO:0008643 carbohydrate transport
GO:0018146 keratan sulfate biosynthetic process
GO:0030203 glycosaminoglycan metabolic process
GO:0042339 keratan sulfate metabolic process
GO:0044281 small molecule metabolic process
GO:0055085 transmembrane transport
GO:1901264 carbohydrate derivative transport
GO:1901679 nucleotide transmembrane transport
Cellular Component
GO:0000139 Golgi membrane
GO:0005575 cellular_component
GO:0016021 integral component of membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000033114
View Gene Order
ENSBTAG00000019939
Not yet available
Pathways
NETPATH
REACTOME
REACT_22151
Transport of nucleotide sugars pathway
REACT_22285
Transport of vitamins, nucleosides, and related molecules pathway
REACT_121120
Keratan sulfate biosynthesis pathway
REACT_121248
HS-GAG biosynthesis pathway
REACT_15518
Transmembrane transport of small molecules pathway
REACT_147853
Mucopolysaccharidoses pathway
REACT_200783
Myoclonic epilepsy of Lafora pathway
REACT_267711
Defective B4GALT7 causes EDS, progeroid type pathway
REACT_267713
Defective CHST6 causes MCDC1 pathway
REACT_121288
Keratan sulfate/keratin metabolism pathway
REACT_147719
MPS VI - Maroteaux-Lamy syndrome pathway
REACT_267645
Defective PAPSS2 causes SEMD-PA pathway
REACT_474
Metabolism of carbohydrates pathway
REACT_147749
MPS IIID - Sanfilippo syndrome D pathway
REACT_267662
Defective SLC26A2 causes chondrodysplasias pathway
REACT_147739
MPS IX - Natowicz syndrome pathway
REACT_267674
Defective EXT1 causes exostoses 1, TRPS2 and CHDS pathway
REACT_267642
Defective CHST14 causes EDS, musculocontractural type pathway
REACT_121314
Heparan sulfate/heparin (HS-GAG) metabolism pathway
REACT_147798
MPS IV - Morquio syndrome B pathway
REACT_267659
Defective B3GAT3 causes JDSSDHD pathway
REACT_267708
Defective CHST3 causes SEDCJD pathway
REACT_147825
MPS IV - Morquio syndrome A pathway
REACT_267654
Defective EXT2 causes exostoses 2 pathway
REACT_267707
Diseases associated with glycosaminoglycan metabolism pathway
REACT_147734
MPS II - Hunter syndrome pathway
REACT_267635
Defective B4GALT1 causes B4GALT1-CDG (CDG-2d) pathway
REACT_121315
Glycosaminoglycan metabolism pathway
REACT_267705
Diseases of glycosylation pathway
REACT_147759
MPS VII - Sly syndrome pathway
REACT_267682
Defective CHSY1 causes TPBS pathway
REACT_111217
Metabolism pathway
REACT_147857
MPS I - Hurler syndrome pathway
REACT_147753
MPS IIIA - Sanfilippo syndrome A pathway
REACT_147860
MPS IIIC - Sanfilippo syndrome C pathway
REACT_19118
SLC-mediated transmembrane transport pathway
REACT_116125
Disease pathway
REACT_200833
Glycogen storage diseases pathway
REACT_147788
MPS IIIB - Sanfilippo syndrome B pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt
TrEMBL Q5VZJ2
UniProt Splice Variant
Entrez Gene 11046
UniGene Hs.619530
RefSeq NM_001286990 NM_007001 XM_005251678
HUGO HGNC:20799
OMIM 609182
CCDS CCDS6717 CCDS69625
HPRD 16456
IMGT
EMBL AL160269
GenPept
RNA Seq Atlas 11046

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca