InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: SLC35D2

Summary

InnateDB Protein

IDBP-77343.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SLC35D2

Protein Name

solute carrier family 35, member D2

Synonyms

hfrc; HFRC1; SQV7L; UGTrel8;

Species

Homo sapiens

Ensembl Protein

ENSP00000364408

InnateDB Gene

IDBG-77339 (SLC35D2)

Protein Structure

UniProt Annotation

Function

Antiporter transporting nucleotide sugars such as UDP-N- acetylglucosamine (UDP-GlcNAc), UDP-glucose (UDP-Glc) and GDP- mannose (GDP-Man) pooled in the cytosol into the lumen of the Golgi in exchange for the corresponding nucleosides monophosphates (UMP for UDP-sugars and GMP for GDP-sugars). May take part in heparan sulfate synthesis by supplying UDP-Glc-NAc, the donor substrate, and thus be involved in growth factor signaling. {ECO:0000269PubMed:15082721, ECO:0000269PubMed:15607426}.

Subcellular Localization

Golgi apparatus membrane {ECO:0000269PubMed:15082721, ECO:0000269PubMed:15607426}; Multi- pass membrane protein {ECO:0000269PubMed:15082721, ECO:0000269PubMed:15607426}.

Disease Associations

Tissue Specificity

Highly expressed in heart, kidney, small intestine, placenta, lung and peripheral blood leukocyte. Weakly expressed in skeletal muscle and spleen. Not expressed in brain, colon and thymus. {ECO:0000269PubMed:15607426}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005338	nucleotide-sugar transmembrane transporter activity

Biological Process

GO:0005975	carbohydrate metabolic process
GO:0006024	glycosaminoglycan biosynthetic process
GO:0008150	biological_process
GO:0008643	carbohydrate transport
GO:0018146	keratan sulfate biosynthetic process
GO:0030203	glycosaminoglycan metabolic process
GO:0042339	keratan sulfate metabolic process
GO:0044281	small molecule metabolic process
GO:0055085	transmembrane transport
GO:1901264	carbohydrate derivative transport
GO:1901679	nucleotide transmembrane transport