Version 5.4
Homo sapiens Gene: SLPI
Summary
InnateDB Gene IDBG-77353.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SLPI
Gene Name secretory leukocyte peptidase inhibitor
Synonyms ALK1; ALP; BLPI; HUSI; HUSI-I; MPI; WAP4; WFDC4
Species Homo sapiens
Ensembl Gene ENSG00000124107
Encoded Proteins
IDBP-77355
secretory leukocyte peptidase inhibitor
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a secreted inhibitor which protects epithelial tissues from serine proteases. It is found in various secretions including seminal plasma, cervical mucus, and bronchial secretions, and has affinity for trypsin, leukocyte elastase, and cathepsin G. Its inhibitory effect contributes to the immune response by protecting epithelial surfaces from attack by endogenous proteolytic enzymes; the protein is also thought to have broad-spectrum anti-biotic activity. [provided by RefSeq, Jul 2008]
This gene encodes a secreted inhibitor which protects epithelial tissues from serine proteases. It is found in various secretions including seminal plasma, cervical mucus, and bronchial secretions, and has affinity for trypsin, leukocyte elastase, and cathepsin G. Its inhibitory effect contributes to the immune response by protecting epithelial surfaces from attack by endogenous proteolytic enzymes; the protein is also thought to have broad-spectrum anti-biotic activity. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 20:45252239-45254564
Strand Reverse strand
Band q13.12
Transcripts
ENST00000338380 ENSP00000342082
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.
Experimentally validated
Total 7 [view]
Protein-Protein 3 [view]
Protein-DNA 4 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004866 endopeptidase inhibitor activity
GO:0004867 serine-type endopeptidase inhibitor activity
GO:0005515 protein binding
GO:0019899 enzyme binding
GO:0030414 peptidase inhibitor activity
Biological Process
GO:0010951 negative regulation of endopeptidase activity
GO:0032091 negative regulation of protein binding
GO:0045071 negative regulation of viral genome replication
Cellular Component
GO:0005576 extracellular region
GO:0031012 extracellular matrix
GO:0070062 extracellular vesicular exosome
Orthologs
No orthologs found for this gene
Cross-References
SwissProt P03973
TrEMBL Q6LDI0
UniProt Splice Variant
Entrez Gene 6590
UniGene
RefSeq NM_003064
HUGO HGNC:11092
OMIM 107285
CCDS CCDS13347
HPRD
IMGT
EMBL AF114471 AK312192 AL035660 BC020708 CH471077 M74444 X04470 X04502 X04503
GenPept AAA60559 AAD19661 AAH20708 BAG35125 CAA28158 CAA28187 CAA28188 CAB64235 EAW75869
RNA Seq Atlas 6590

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca