InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: SLPI

Summary

InnateDB Protein

IDBP-77355.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SLPI

Protein Name

secretory leukocyte peptidase inhibitor

Synonyms

ALK1; ALP; BLPI; HUSI; HUSI-I; MPI; WAP4; WFDC4;

Species

Homo sapiens

Ensembl Protein

ENSP00000342082

InnateDB Gene

IDBG-77353 (SLPI)

Protein Structure

UniProt Annotation

Function

Acid-stable proteinase inhibitor with strong affinities for trypsin, chymotrypsin, elastase, and cathepsin G. May prevent elastase-mediated damage to oral and possibly other mucosal tissues.

Subcellular Localization

Secreted.

Disease Associations

Tissue Specificity

Mucous fluids.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.

Experimentally validated
Total	7 [view]
Protein-Protein	3 [view]
Protein-DNA	4 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004866	endopeptidase inhibitor activity
GO:0004867	serine-type endopeptidase inhibitor activity
GO:0005515	protein binding
GO:0019899	enzyme binding
GO:0030414	peptidase inhibitor activity

Biological Process

GO:0010951	negative regulation of endopeptidase activity
GO:0032091	negative regulation of protein binding
GO:0045071	negative regulation of viral genome replication