Version 5.4
Homo sapiens Gene: EIF4EBP2
Summary
InnateDB Gene IDBG-77416.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol EIF4EBP2
Gene Name eukaryotic translation initiation factor 4E binding protein 2
Synonyms 4EBP2; PHASII
Species Homo sapiens
Ensembl Gene ENSG00000148730
Encoded Proteins
IDBP-77418
eukaryotic translation initiation factor 4E binding protein 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation from Orthologs
Summary
PMID 25531441
[Mus musculus] Genetic deletion of Eif4ebp1 or Eif4ebp2 potentiates innate antiviral immunity by enhancing translation of Irf7.
Entrez Gene
Summary This gene encodes a member of the eukaryotic translation initiation factor 4E binding protein family. The gene products of this family bind eIF4E and inhibit translation initiation. However, insulin and other growth factors can release this inhibition via a phosphorylation-dependent disruption of their binding to eIF4E. Regulation of protein production through these gene products have been implicated in cell proliferation, cell differentiation and viral infection. [provided by RefSeq, Oct 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 10:70404379-70428618
Strand Forward strand
Band q22.1
Transcripts
ENST00000373218 ENSP00000362314
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 10 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.
Experimentally validated
Total 10 [view]
Protein-Protein 6 [view]
Protein-DNA 3 [view]
Protein-RNA 1 [view]
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 4 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0008190 eukaryotic initiation factor 4E binding
Biological Process
GO:0006412 translation
GO:0008286 insulin receptor signaling pathway
GO:0019933 cAMP-mediated signaling
GO:0045947 negative regulation of translational initiation
Cellular Component
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000020091
View Gene Order
ENSBTAG00000019124
Not yet available
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.603165 Hs.621200 Hs.705686
RefSeq NM_004096
HUGO
OMIM
CCDS CCDS7303
HPRD 03747
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca