InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: EIF4EBP2

Summary

InnateDB Protein

IDBP-77418.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

EIF4EBP2

Protein Name

eukaryotic translation initiation factor 4E binding protein 2

Synonyms

4EBP2; PHASII;

Species

Homo sapiens

Ensembl Protein

ENSP00000362314

InnateDB Gene

IDBG-77416 (EIF4EBP2)

Protein Structure

UniProt Annotation

Function

Regulates eIF4E activity by preventing its assembly into the eIF4F complex. Mediates the regulation of protein translation by hormones, growth factors and other stimuli that signal through the MAP kinase pathway.

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 10 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.

Experimentally validated
Total	10 [view]
Protein-Protein	6 [view]
Protein-DNA	3 [view]
Protein-RNA	1 [view]
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	4 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0008190	eukaryotic initiation factor 4E binding

Biological Process

GO:0006412	translation
GO:0008286	insulin receptor signaling pathway
GO:0019933	cAMP-mediated signaling
GO:0045947	negative regulation of translational initiation