Version 5.4
Homo sapiens Gene: RALBP1
Summary
InnateDB Gene IDBG-775.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol RALBP1
Gene Name ralA binding protein 1
Synonyms RIP1; RLIP1; RLIP76
Species Homo sapiens
Ensembl Gene ENSG00000017797
Encoded Proteins
IDBP-777
ralA binding protein 1
IDBP-779
ralA binding protein 1
IDBP-363213
ralA binding protein 1
IDBP-726865
IDBP-727184
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary RALBP1 plays a role in receptor-mediated endocytosis and is a downstream effector of the small GTP-binding protein RAL (see RALA; MIM 179550). Small G proteins, such as RAL, have GDP-bound inactive and GTP-bound active forms, which shift from the inactive to the active state through the action of RALGDS (MIM 601619), which in turn is activated by RAS (see HRAS; MIM 190020) (summary by Feig, 2003 [PubMed 12888294]).[supplied by OMIM, Nov 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 18:9475009-9538116
Strand Forward strand
Band p11.22
Transcripts
ENST00000019317 ENSP00000019317
ENST00000383432 ENSP00000372924
ENST00000458039 ENSP00000411556
ENST00000585015 ENSP00000463693
ENST00000577221 ENSP00000462549
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 42 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.
Experimentally validated
Total 42 [view]
Protein-Protein 42 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 4 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005096 GTPase activator activity
GO:0005515 protein binding
GO:0016887 ATPase activity
GO:0017160 Ral GTPase binding
GO:0030675 Rac GTPase activator activity
GO:0043492 ATPase activity, coupled to movement of substances
GO:0048365 Rac GTPase binding
Biological Process
GO:0006200 ATP catabolic process
GO:0006810 transport
GO:0006935 chemotaxis
GO:0007165 signal transduction
GO:0007264 small GTPase mediated signal transduction
GO:0032855 positive regulation of Rac GTPase activity
GO:0043087 regulation of GTPase activity
GO:0043089 positive regulation of Cdc42 GTPase activity
GO:0051056 regulation of small GTPase mediated signal transduction
Cellular Component
GO:0005622 intracellular
GO:0005829 cytosol
GO:0016020 membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000024096
View Gene Order
ENSBTAG00000021250
Not yet available
Pathways
NETPATH
NetPath_4
EGFR1 pathway
REACTOME
REACT_11051
Rho GTPase cycle pathway
REACT_11044
Signaling by Rho GTPases pathway
REACT_111102
Signal Transduction pathway
KEGG
hsa05212
Pancreatic cancer pathway
hsa05200
Pathways in cancer pathway
INOH
PID NCI
rac1_reg_pathway
Regulation of RAC1 activity
cdc42_reg_pathway
Regulation of CDC42 activity
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.528993 Hs.713842
RefSeq NM_006788 XM_006722295 XM_006722296
HUGO
OMIM
CCDS CCDS11845
HPRD 09013
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca