InnateDB Protein
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IDBP-779.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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RALBP1
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Protein Name
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ralA binding protein 1
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Synonyms
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RIP1; RLIP1; RLIP76;
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000372924
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InnateDB Gene
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IDBG-775 (RALBP1)
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Protein Structure
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Function |
Can activate specifically hydrolysis of GTP bound to RAC1 and CDC42, but not RALA. Mediates ATP-dependent transport of S-(2,4-dinitrophenyl)-glutathione (DNP-SG) and doxorubicin (DOX) and is the major ATP-dependent transporter of glutathione conjugates of electrophiles (GS-E) and DOX in erythrocytes. Can catalyze transport of glutathione conjugates and xenobiotics, and may contribute to the multidrug resistance phenomenon. Serves as a scaffold protein that brings together proteins forming an endocytotic complex during interphase and also with CDK1 to switch off endocytosis, One of its substrates would be EPN1/Epsin. {ECO:0000269PubMed:11437348, ECO:0000269PubMed:12775724, ECO:0000269PubMed:7673236}.
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Subcellular Localization |
Membrane {ECO:0000269PubMed:11437348}; Peripheral membrane protein {ECO:0000269PubMed:11437348}.
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Disease Associations |
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Tissue Specificity |
Expressed ubiquitously but at low levels. Shows a strong expression in the erythrocytes. {ECO:0000269PubMed:11437348}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 42 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.
Experimentally validated |
Total |
42
[view]
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Protein-Protein |
42
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
4 [view]
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR000198
Rho GTPase-activating protein domain
IPR008936
Rho GTPase activation protein
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PFAM |
PF00620
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PRINTS |
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PIRSF |
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SMART |
SM00324
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TIGRFAMs |
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Modification |
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SwissProt |
Q15311
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PhosphoSite |
PhosphoSite-Q15311
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TrEMBL |
Q59E87
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UniProt Splice Variant |
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Entrez Gene |
10928
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UniGene |
Hs.713842
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RefSeq |
NP_006779
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HUGO |
HGNC:9841
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OMIM |
605801
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CCDS |
CCDS11845
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HPRD |
09013
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IMGT |
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EMBL |
AB209924
AP005432
BC013126
CH471113
L42542
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GenPept |
AAB00103
AAH13126
BAD93161
EAX01601
EAX01602
EAX01604
EAX01605
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