InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: MICB

Summary

InnateDB Gene

IDBG-77697.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

MICB

Gene Name

MHC class I polypeptide-related sequence B

Synonyms

PERB11.2

Species

Homo sapiens

Ensembl Gene

ENSG00000204516

Encoded Proteins

IDBP-77699

MHC class I polypeptide-related sequence B

IDBP-231332

MHC class I polypeptide-related sequence B

IDBP-593993

MHC class I polypeptide-related sequence B

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene encodes a heavily glycosylated protein which is a ligand for the NKG2D type II receptor. Binding of the ligand activates the cytolytic response of natural killer (NK) cells, CD8 alphabeta T cells, and gammadelta T cells which express the receptor. This protein is stress-induced and is similar to MHC class I molecules; however, it does not associate with beta-2-microglobulin or bind peptides. [provided by RefSeq, Jul 2008]
This gene encodes a heavily glycosylated protein which is a ligand for the NKG2D type II receptor. Binding of the ligand activates the cytolytic response of natural killer (NK) cells, CD8 alphabeta T cells, and gammadelta T cells which express the receptor. This protein is stress-induced and is similar to MHC class I molecules; however, it does not associate with beta-2-microglobulin or bind peptides. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 6:31494881-31511124

Strand

Forward strand

Band

p21.33

Transcripts

ENST00000252229	ENSP00000252229
ENST00000399150	ENSP00000382103
ENST00000494577
ENST00000538442	ENSP00000442345

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.

Experimentally validated
Total	5 [view]
Protein-Protein	2 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	2 [view]
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0046703	natural killer cell lectin-like receptor binding

Biological Process

GO:0002429	immune response-activating cell surface receptor signaling pathway
GO:0006955	immune response
GO:0006979	response to oxidative stress
GO:0009408	response to heat
GO:0016032	viral process
GO:0019835	cytolysis
GO:0019882	antigen processing and presentation
GO:0032526	response to retinoic acid
GO:0046629	gamma-delta T cell activation
GO:0050689	negative regulation of defense response to virus by host
GO:0050776	regulation of immune response

Cellular Component

GO:0005886	plasma membrane
GO:0009986	cell surface
GO:0016021	integral component of membrane

Orthologs

No orthologs found for this gene

Pathways

NETPATH

REACTOME

REACT_11152

Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell pathway

REACT_75774

Adaptive Immune System pathway

REACT_6900

Immune System pathway

KEGG

hsa04650

Natural killer cell mediated cytotoxicity pathway

INOH

PID NCI

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Hs.639203 Hs.731446

RefSeq

NM_001289160 NM_001289161 NM_005931

HUGO

OMIM

CCDS

CCDS43449 CCDS75422 CCDS75423

HPRD

03894

IMGT

EMBL

GenPept

RNA Seq Atlas