InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: MICB

Summary

InnateDB Protein

IDBP-231332.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

MICB

Protein Name

MHC class I polypeptide-related sequence B

Synonyms

PERB11.2;

Species

Homo sapiens

Ensembl Protein

ENSP00000382103

InnateDB Gene

IDBG-77697 (MICB)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.

Experimentally validated
Total	5 [view]
Protein-Protein	2 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	2 [view]
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0046703	natural killer cell lectin-like receptor binding

Biological Process

GO:0002429	immune response-activating cell surface receptor signaling pathway
GO:0006955	immune response
GO:0006979	response to oxidative stress
GO:0009408	response to heat
GO:0016032	viral process
GO:0019835	cytolysis
GO:0019882	antigen processing and presentation
GO:0032526	response to retinoic acid
GO:0046629	gamma-delta T cell activation
GO:0050689	negative regulation of defense response to virus by host
GO:0050776	regulation of immune response

Cellular Component

GO:0005886	plasma membrane
GO:0009986	cell surface
GO:0016021	integral component of membrane

Protein Structure and Domains

PDB ID

InterPro

IPR001039 MHC class I alpha chain, alpha1 alpha2 domains
IPR003597 Immunoglobulin C1-set
IPR007110 Immunoglobulin-like domain
IPR011162 MHC classes I/II-like antigen recognition protein

PFAM

PF00129
PF07654

PRINTS

PIRSF

SMART

SM00407

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q29980