Version 5.4
Homo sapiens Gene: TMOD1
Summary
InnateDB Gene IDBG-77762.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol TMOD1
Gene Name tropomodulin 1
Synonyms D9S57E; ETMOD; TMOD
Species Homo sapiens
Ensembl Gene ENSG00000136842
Encoded Proteins
IDBP-77764
tropomodulin 1
IDBP-77766
tropomodulin 1
IDBP-240026
tropomodulin 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a member of the tropomodulin family. The encoded protein is an actin-capping protein that regulates tropomyosin by binding to its N-terminus, inhibiting depolymerization and elongation of the pointed end of actin filaments and thereby influencing the structure of the erythrocyte membrane skeleton. Multiple transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Oct 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome 9:97501180-97601748
Strand Forward strand
Band q22.33
Transcripts
ENST00000259365 ENSP00000259365
ENST00000375175 ENSP00000364318
ENST00000395211 ENSP00000378637
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 3 [view]
Protein-Protein 3 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003779 actin binding
GO:0005523 tropomyosin binding
Biological Process
GO:0006936 muscle contraction
GO:0008344 adult locomotory behavior
GO:0030049 muscle filament sliding
GO:0030239 myofibril assembly
GO:0051694 pointed-end actin filament capping
Cellular Component
GO:0005829 cytosol
GO:0005856 cytoskeleton
GO:0008180 COP9 signalosome
GO:0016020 membrane
GO:0030016 myofibril
GO:0030863 cortical cytoskeleton
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000028328
View Gene Order
ENSBTAG00000014719
Not yet available
Pathways
NETPATH
REACTOME
REACT_16969
Striated Muscle Contraction pathway
REACT_17044
Muscle contraction pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.404289
RefSeq NM_001166116 NM_003275
HUGO
OMIM
CCDS CCDS6726
HPRD 01838
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca