Version 5.4
Homo sapiens Protein: TMOD1
Summary
InnateDB Protein IDBP-240026.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol TMOD1
Protein Name tropomodulin 1
Synonyms D9S57E; ETMOD; TMOD;
Species Homo sapiens
Ensembl Protein ENSP00000378637
InnateDB Gene IDBG-77762 (TMOD1)
Protein Structure
UniProt Annotation
Function Blocks the elongation and depolymerization of the actin filaments at the pointed end. The Tmod/TM complex contributes to the formation of the short actin protofilament, which in turn defines the geometry of the membrane skeleton. May play an important role in regulating the organization of actin filaments by preferentially binding to a specific tropomyosin isoform at its N-terminus. {ECO:0000269PubMed:8002995}.
Subcellular Localization Cytoplasm, cytoskeleton.
Disease Associations
Tissue Specificity Highly expressed in the erythrocyte, heart and skeletal muscle.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 3 [view]
Protein-Protein 3 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003779 actin binding
GO:0005523 tropomyosin binding
Biological Process
GO:0030049 muscle filament sliding
GO:0051694 pointed-end actin filament capping
Cellular Component
GO:0005829 cytosol
GO:0008180 COP9 signalosome
Protein Structure and Domains
PDB ID
InterPro IPR004934 Tropomodulin
PFAM PF03250
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt P28289
PhosphoSite PhosphoSite-P28289
TrEMBL
UniProt Splice Variant
Entrez Gene 7111
UniGene Hs.404289
RefSeq NP_001159588
HUGO HGNC:11871
OMIM 190930
CCDS CCDS6726
HPRD 01838
IMGT
EMBL AF288147 AF288148 AF288149 AF288150 AF288151 AF288152 AF288153 AF288154 AF288155 AK314533 AL162385 BC002660 M77016
GenPept AAA61224 AAG30124 AAH02660 BAG37124 CAI12854

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca