Version 5.4
Homo sapiens Gene: MICU1
Summary
InnateDB Gene IDBG-77896.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol MICU1
Gene Name mitochondrial calcium uptake 1
Synonyms CALC; CBARA1; EFHA3; MPXPS
Species Homo sapiens
Ensembl Gene ENSG00000107745
Encoded Proteins
IDBP-77898
mitochondrial calcium uptake 1
IDBP-232236
mitochondrial calcium uptake 1
IDBP-232238
mitochondrial calcium uptake 1
IDBP-379535
mitochondrial calcium uptake 1
IDBP-584070
mitochondrial calcium uptake 1
IDBP-808443
mitochondrial calcium uptake 1
IDBP-808444
mitochondrial calcium uptake 1
IDBP-808446
mitochondrial calcium uptake 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes an essential regulator of mitochondrial Ca2+ uptake under basal conditions. The encoded protein interacts with the mitochondrial calcium uniporter, a mitochondrial inner membrane Ca2+ channel, and is essential in preventing mitochondrial Ca2+ overload, which can cause excessive production of reactive oxygen species and cell stress. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Mar 2013]
Gene Information
Type Protein coding
Genomic Location Chromosome 10:72367327-72626191
Strand Reverse strand
Band q22.1
Transcripts
ENST00000361114 ENSP00000354415
ENST00000398763 ENSP00000381747
ENST00000398761 ENSP00000381745
ENST00000418483 ENSP00000402470
ENST00000476605 ENSP00000432492
ENST00000489666 ENSP00000474809
ENST00000605385
ENST00000603173
ENST00000603011 ENSP00000474192
ENST00000604529
ENST00000604238 ENSP00000474775
ENST00000604025
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
Experimentally validated
Total 6 [view]
Protein-Protein 5 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005509 calcium ion binding
GO:0005515 protein binding
GO:0046982 protein heterodimerization activity
Biological Process
GO:0006851 mitochondrial calcium ion transport
GO:0006952 defense response
GO:0036444 calcium ion import into mitochondrion
GO:0051260 protein homooligomerization
GO:0051560 mitochondrial calcium ion homeostasis
GO:0051561 positive regulation of mitochondrial calcium ion concentration
GO:0070509 calcium ion import
Cellular Component
GO:0005622 intracellular
GO:0005739 mitochondrion
GO:0005743 mitochondrial inner membrane
GO:0005758 mitochondrial intermembrane space
GO:0032592 integral component of mitochondrial membrane
GO:0034704 calcium channel complex
GO:1990246 uniplex complex
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000020111
View Gene Order
ENSBTAG00000005807
Not yet available
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.524367 Hs.597970
RefSeq NM_001195518 NM_001195519 NM_006077 XM_005269383 XM_005269384 XM_005269386 XM_005269387
HUGO
OMIM
CCDS CCDS55714 CCDS55715
HPRD 05471
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca