Version 5.4
Bos taurus Gene: MICU1
Summary
InnateDB Gene IDBG-629968.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol MICU1
Gene Name Calcium uptake protein 1, mitochondrial
Synonyms CBARA1
Species Bos taurus
Ensembl Gene ENSBTAG00000005807
Encoded Proteins
IDBP-681403
Calcium uptake protein 1, mitochondrial
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000107745:
This gene encodes an essential regulator of mitochondrial Ca2+ uptake under basal conditions. The encoded protein interacts with the mitochondrial calcium uniporter, a mitochondrial inner membrane Ca2+ channel, and is essential in preventing mitochondrial Ca2+ overload, which can cause excessive production of reactive oxygen species and cell stress. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Mar 2013]
Gene Information
Type Protein coding
Genomic Location Chromosome 28:28562368-28777941
Strand Reverse strand
Band
Transcripts
ENSBTAT00000007636 ENSBTAP00000007636
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.
Predicted by orthology
Total 5 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005509 calcium ion binding
GO:0005515 protein binding
GO:0046872 metal ion binding
GO:0046982 protein heterodimerization activity
Biological Process
GO:0006810 transport
GO:0006811 ion transport
GO:0006816 calcium ion transport
GO:0006851 mitochondrial calcium ion transport
GO:0036444 calcium ion import into mitochondrion
GO:0051260 protein homooligomerization
GO:0051560 mitochondrial calcium ion homeostasis
GO:0051561 positive regulation of mitochondrial calcium ion concentration
GO:0070509 calcium ion import
Cellular Component
GO:0005739 mitochondrion
GO:0005743 mitochondrial inner membrane
GO:0005758 mitochondrial intermembrane space
GO:0016020 membrane
GO:0032592 integral component of mitochondrial membrane
GO:0034704 calcium channel complex
GO:1990246 uniplex complex
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000107745
View Gene Order
ENSMUSG00000020111
View Gene Order
Cross-References
SwissProt Q0IIL1
TrEMBL
UniProt Splice Variant
Entrez Gene 507899
UniGene Bt.10107
RefSeq NM_001075338 XM_005226354 XM_005226355
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL BC122590
GenPept AAI22591
RNA Seq Atlas 507899

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca