Version 5.4
Homo sapiens Gene: BOLL
Summary
InnateDB Gene IDBG-78064.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol BOLL
Gene Name bol, boule-like (Drosophila)
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000152430
Encoded Proteins
IDBP-78066
bol, boule-like (Drosophila)
IDBP-78068
bol, boule-like (Drosophila)
IDBP-245943
bol, boule-like (Drosophila)
IDBP-388191
bol, boule-like (Drosophila)
IDBP-388192
bol, boule-like (Drosophila)
IDBP-388193
bol, boule-like (Drosophila)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene belongs to the DAZ gene family required for germ cell development. It encodes an RNA-binding protein which is more similar to Drosophila Boule than to human proteins encoded by genes DAZ (deleted in azoospermia) or DAZL (deleted in azoospermia-like). Loss of this gene function results in the absence of sperm in semen (azoospermia). Histological studies demonstrated that the primary defect is at the meiotic G2/M transition. Two alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 2:197726879-197786762
Strand Reverse strand
Band q33.1
Transcripts
ENST00000321801 ENSP00000314792
ENST00000282278 ENSP00000282278
ENST00000392296 ENSP00000376116
ENST00000430004 ENSP00000397711
ENST00000434976 ENSP00000416911
ENST00000433157 ENSP00000396099
ENST00000468827
ENST00000486206
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0000166 nucleotide binding
GO:0003676 nucleic acid binding
GO:0003723 RNA binding
GO:0005515 protein binding
GO:0008494 translation activator activity
Biological Process
GO:0007126 meiotic nuclear division
GO:0007275 multicellular organismal development
GO:0007283 spermatogenesis
GO:0030154 cell differentiation
GO:0045948 positive regulation of translational initiation
Cellular Component
GO:0005737 cytoplasm
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000025977
View Gene Order
ENSBTAG00000031614
Not yet available
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.169797 Hs.692026
RefSeq NM_001284358 NM_001284361 NM_001284362 NM_033030 NM_197970
HUGO
OMIM
CCDS CCDS2324 CCDS2325 CCDS63081
HPRD
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca