Homo sapiens Gene: NCR3
Summary
InnateDB Gene IDBG-78112.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol NCR3
Gene Name natural cytotoxicity triggering receptor 3
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000204475
Encoded Proteins
natural cytotoxicity triggering receptor 3
natural cytotoxicity triggering receptor 3
natural cytotoxicity triggering receptor 3
natural cytotoxicity triggering receptor 3
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene is a natural cytotoxicity receptor (NCR) that may aid NK cells in the lysis of tumor cells. The encoded protein interacts with CD3-zeta (CD247), a T-cell receptor. A single nucleotide polymorphism in the 5' untranslated region of this gene has been associated with mild malaria suceptibility. Three transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, May 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 6:31588895-31592985
Strand Reverse strand
Band p21.33
Transcripts
ENST00000340027 ENSP00000342156
ENST00000376073 ENSP00000365241
ENST00000376072 ENSP00000365240
ENST00000376071 ENSP00000365239
ENST00000491161
ENST00000495600
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
Experimentally validated
Total 4 [view]
Protein-Protein 4 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0006954 inflammatory response
GO:0006955 immune response
GO:0008037 cell recognition
GO:0045954 positive regulation of natural killer cell mediated cytotoxicity
Cellular Component
GO:0005887 integral component of plasma membrane
Orthologs
No orthologs found for this gene
Pathways
NETPATH
REACTOME
KEGG
Natural killer cell mediated cytotoxicity pathway
INOH
PID NCI
Cross-References
SwissProt O14931
TrEMBL Q05D23
UniProt Splice Variant
Entrez Gene 259197
UniGene
RefSeq NM_001145466 NM_001145467 NM_147130 XM_006715049 XM_006725903
HUGO HGNC:19077
OMIM 611550
CCDS CCDS34397 CCDS47401 CCDS47402
HPRD
IMGT
EMBL AB055881 AF031136 AF031137 AF031138 AF129756 AJ223153 AL662801 AL662847 AL929587 BA000025 BC018752 BC052582 BX248519 BX927320 CH471081 CR753892 CR759886 CR759905 CR942185 Y14768
GenPept AAB86578 AAB86579 AAB86580 AAD18088 AAH18752 AAH52582 BAB63393 BAB78472 CAA75063 CAA75064 CAA75065 CAA75066 CAA75067 CAA75068 CAB54004 CAI17688 CAI17689 CAI17690 CAI17691 CAI18302 CAI18303 CAI18304 CAI18305 CAI18660 CAI18661 CAI18662 CAI18663 CAI41953 CAI41954 CAI41955 CAI41956 CAQ06951 CAQ06953 CAQ06954 CAQ07224 CAQ07226 CAQ07227 CAQ07727 CAQ07729 CAQ07730 CAQ08772 CAQ08774 CAQ08775 CAQ10009 CAQ10011 CAQ10012 EAX03439 EAX03440 EAX03441
RNA Seq Atlas 259197