Version 5.4
Homo sapiens Protein: NCR3
Summary
InnateDB Protein IDBP-78120.7
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol NCR3
Protein Name natural cytotoxicity triggering receptor 3
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000365240
InnateDB Gene IDBG-78112 (NCR3)
Protein Structure
UniProt Annotation
Function Cytotoxicity-activating receptor that contributes to the increased efficiency of activated natural killer (NK) cells to mediate tumor cell lysis. Engagement of NCR3 by BAG6 also promotes dendritic cell (DC) maturation, both through killing those DCs that did not properly acquire a mature phenotype, and inducing NK cells to release TNFA and IFNG, which promotes DC maturation. {ECO:0000269PubMed:10562324, ECO:0000269PubMed:15784725, ECO:0000269PubMed:18852879}.
Subcellular Localization Cell membrane {ECO:0000269PubMed:10562324}; Single-pass type I membrane protein {ECO:0000269PubMed:10562324}.
Disease Associations
Tissue Specificity Selectively expressed by all resting and activated NK cells and weakly expressed in spleen. {ECO:0000269PubMed:10562324, ECO:0000269Ref.2}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
Experimentally validated
Total 4 [view]
Protein-Protein 4 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0006954 inflammatory response
GO:0006955 immune response
GO:0008037 cell recognition
GO:0045954 positive regulation of natural killer cell mediated cytotoxicity
Cellular Component
GO:0005887 integral component of plasma membrane
Protein Structure and Domains
PDB ID
InterPro IPR003599 Immunoglobulin subtype
IPR007110 Immunoglobulin-like domain
IPR013106 Immunoglobulin V-set domain
PFAM PF07686
PRINTS
PIRSF
SMART SM00409
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt O14931
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 259197
UniGene
RefSeq NP_001138939
HUGO HGNC:19077
OMIM 611550
CCDS CCDS47402
HPRD 11384
IMGT
EMBL AB055881 AF031136 AF031137 AF031138 AF129756 AJ223153 AL662801 AL662847 AL929587 BA000025 BC052582 BX248519 BX927320 CH471081 CR753892 CR759886 CR759905 CR942185 Y14768
GenPept AAB86578 AAB86579 AAB86580 AAD18088 AAH52582 BAB63393 BAB78472 CAA75063 CAA75064 CAA75065 CAA75066 CAA75067 CAA75068 CAB54004 CAI17688 CAI17689 CAI17690 CAI17691 CAI18302 CAI18303 CAI18304 CAI18305 CAI18660 CAI18661 CAI18662 CAI18663 CAI41953 CAI41954 CAI41955 CAI41956 CAQ06951 CAQ06953 CAQ06954 CAQ07224 CAQ07226 CAQ07227 CAQ07727 CAQ07729 CAQ07730 CAQ08772 CAQ08774 CAQ08775 CAQ10009 CAQ10011 CAQ10012 EAX03439 EAX03440

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca