Homo sapiens Gene: TNNC2

Summary
InnateDB Gene IDBG-78217.5
Last Modified 2012-02-14   [Report errors or provide feedback]
Gene Symbol TNNC2
Gene Name troponin C type 2 (fast)
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000101470
Encoded Proteins
IDBP-78219 troponin C type 2 (fast)
IDBP-78221 troponin C type 2 (fast)
Entrez Gene
Summary Troponin (Tn), a key protein complex in the regulation of striated muscle contraction, is composed of 3 subunits. The Tn-I subunit inhibits actomyosin ATPase, the Tn-T subunit binds tropomyosin and Tn-C, while the Tn-C subunit binds calcium and overcomes the inhibitory action of the troponin complex on actin filaments. The protein encoded by this gene is the Tn-C subunit. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 20: 44451853-44462384
Strand Reverse strand
Band q13.12
Transcripts
ENST00000372557  ENSP00000361638
ENST00000372555  ENSP00000361636
Interactions
Number of Interactions   This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
 
Gene Ontology
Accession GO Term
Molecular Function
GO:0003779 actin binding
GO:0005509 calcium ion binding
Biological Process
GO:0003009 skeletal muscle contraction
GO:0006937 regulation of muscle contraction
GO:0007165 signal transduction
GO:0030049 muscle filament sliding
Cellular Component
GO:0005578 proteinaceous extracellular matrix
GO:0005829 cytosol
GO:0005861 troponin complex
Orthologs
Species
Mus musculus
Gene ID Gene Order Method Confidence Comments
ENSMUSG00000017300 RBBH Low Tentative data, uncurated. RBBH derived.
Pathways
NETPATH
REACTOME
REACT_16969 Striated Muscle Contraction
KEGG
hsa04020  Calcium signaling pathway
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt P02585 
TrEMBL C9J7T9 Q6FH92
UniProt Splice Variant
Entrez Gene 7125 
UniGene
RefSeq NM_003279 
HUGO 11944 
OMIM 191039
CCDS CCDS13375 
HPRD 08929
IMGT
EMBL AK291323 AL008726 AL050348 BC005323 CH471077 CR541864 CR541884 M22307 M33771 M33772 X07898
GenPept AAA61197  AAA91854  AAH05323  BAF84012  CAA30737  CAG46662  CAG46682  EAW75802  EAW75803 
ImmGen TNNC2 (murine) 
RNA Seq Atlas 7125