Homo sapiens Gene: TNNC2
Summary
InnateDB Gene IDBG-78217.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol TNNC2
Gene Name troponin C type 2 (fast)
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000101470
Encoded Proteins
troponin C type 2 (fast)
troponin C type 2 (fast)
Protein Structure
Entrez Gene
Summary Troponin (Tn), a key protein complex in the regulation of striated muscle contraction, is composed of 3 subunits. The Tn-I subunit inhibits actomyosin ATPase, the Tn-T subunit binds tropomyosin and Tn-C, while the Tn-C subunit binds calcium and overcomes the inhibitory action of the troponin complex on actin filaments. The protein encoded by this gene is the Tn-C subunit. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 20:45823214-45833745
Strand Reverse strand
Band q13.12
Transcripts
ENST00000372557 ENSP00000361638
ENST00000372555 ENSP00000361636
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003779 actin binding
GO:0005509 calcium ion binding
Biological Process
GO:0003009 skeletal muscle contraction
GO:0006937 regulation of muscle contraction
GO:0007165 signal transduction
GO:0030049 muscle filament sliding
Cellular Component
GO:0005578 proteinaceous extracellular matrix
GO:0005829 cytosol
GO:0005861 troponin complex
Orthologs
Species
Mus musculus
Gene ID
Gene Order
Method
Confidence
Comments
Low
Tentative data, uncurated. RBBH derived.
Pathways
NETPATH
REACTOME
Muscle contraction pathway
Striated Muscle Contraction pathway
KEGG
Calcium signaling pathway pathway
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt P02585
TrEMBL C9J7T9
UniProt Splice Variant
Entrez Gene 7125
UniGene
RefSeq NM_003279
HUGO HGNC:11944
OMIM 191039
CCDS CCDS13375
HPRD 08929
IMGT
EMBL AK291323 AL008726 AL050348 BC005323 CH471077 CR541864 CR541884 M22307 M33771 M33772 X07898
GenPept AAA61197 AAA91854 AAH05323 BAF84012 CAA30737 CAG46662 CAG46682 EAW75802 EAW75803
ImmGen TNNC2 (murine)
RNA Seq Atlas 7125