Version 5.4
Homo sapiens Gene: PLTP
Summary
InnateDB Gene IDBG-78556.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PLTP
Gene Name phospholipid transfer protein
Synonyms BPIFE; HDLCQ9
Species Homo sapiens
Ensembl Gene ENSG00000100979
Encoded Proteins
IDBP-78558
phospholipid transfer protein
IDBP-78560
phospholipid transfer protein
IDBP-78562
phospholipid transfer protein
IDBP-376919
phospholipid transfer protein
IDBP-477077
phospholipid transfer protein
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
PMID 21787334
PLTP may play a pivotal role in inflammation and innate immunity through its ability to accelerate the 'reverse LPS transport' pathway. (Demonstrated in mouse)
InnateDB Annotation from Orthologs
Summary
PMID 21787334
[Mus musculus] Pltp may play a pivotal role in inflammation and innate immunity through its ability to accelerate the 'reverse LPS transport' pathway.
Entrez Gene
Summary The protein encoded by this gene is one of at least two lipid transfer proteins found in human plasma. The encoded protein transfers phospholipids from triglyceride-rich lipoproteins to high density lipoprotein (HDL). In addition to regulating the size of HDL particles, this protein may be involved in cholesterol metabolism. At least two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 20:45898621-45912155
Strand Reverse strand
Band q13.12
Transcripts
ENST00000372431 ENSP00000361508
ENST00000354050 ENSP00000335290
ENST00000372420 ENSP00000361497
ENST00000420868 ENSP00000411671
ENST00000477313 ENSP00000417138
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
Experimentally validated
Total 5 [view]
Protein-Protein 5 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0008289 lipid binding
Biological Process
GO:0006629 lipid metabolic process
GO:0006869 lipid transport
GO:0010189 vitamin E biosynthetic process
GO:0030317 sperm motility
GO:0045087 innate immune response (InnateDB)
Cellular Component
GO:0005576 extracellular region
GO:0005615 extracellular space
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000017754
View Gene Order
ENSBTAG00000000559
Not yet available
Pathways
NETPATH
REACTOME
KEGG
hsa03320
PPAR signaling pathway pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.439312 Hs.735495
RefSeq NM_001242920 NM_001242921 NM_006227 NM_182676 XM_005260439
HUGO
OMIM
CCDS CCDS13386 CCDS13387 CCDS56196 CCDS56197
HPRD 01399
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca