Version 5.4
Homo sapiens Gene: RPA4
Summary
InnateDB Gene IDBG-79086.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol RPA4
Gene Name replication protein A4, 30kDa
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000204086
Encoded Proteins
IDBP-79088
replication protein A4, 30kDa
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a single-stranded DNA-binding protein that is the 30-kDa subunit of the replication protein A complex. Replication protein A is an essential factor for DNA double-strand break repair and cell cycle checkpoint activation. The encoded protein localizes to DNA repair foci and may be involved in the cellular DNA damage response. This protein may also play a role in inhibiting viral replication.[provided by RefSeq, Apr 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome X:96883908-96885467
Strand Forward strand
Band q21.33
Transcripts
ENST00000373040 ENSP00000362131
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 11 experimentally validated interaction(s) in this database.
Experimentally validated
Total 11 [view]
Protein-Protein 10 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003676 nucleic acid binding
GO:0003677 DNA binding
GO:0003697 single-stranded DNA binding
Biological Process
GO:0000077 DNA damage checkpoint
GO:0000082 G1/S transition of mitotic cell cycle
GO:0000278 mitotic cell cycle
GO:0006260 DNA replication
GO:0006270 DNA replication initiation
GO:0006281 DNA repair
GO:0006289 nucleotide-excision repair
GO:0006310 DNA recombination
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005662 DNA replication factor A complex
Orthologs
No orthologs found for this gene
Pathways
NETPATH
REACTOME
REACT_1095
Activation of the pre-replicative complex pathway
REACT_383
DNA Replication pathway
REACT_21267
Mitotic G1-G1/S phases pathway
REACT_734
DNA Replication Pre-Initiation pathway
REACT_1783
G1/S Transition pathway
REACT_115566
Cell Cycle pathway
REACT_1725
M/G1 Transition pathway
REACT_152
Cell Cycle, Mitotic pathway
KEGG
hsa03030
DNA replication pathway
hsa03420
Nucleotide excision repair pathway
hsa03440
Homologous recombination pathway
hsa03430
Mismatch repair pathway
INOH
PID NCI
Cross-References
SwissProt Q13156
TrEMBL
UniProt Splice Variant
Entrez Gene 29935
UniGene Hs.659349
RefSeq NM_013347
HUGO HGNC:30305
OMIM 300767
CCDS CCDS35345
HPRD 06591
IMGT
EMBL AF494047 BC069791 BC069808 BC069824 BC104013 BC104014 U24186 Z86061
GenPept AAB08488 AAH69791 AAH69808 AAH69824 AAI04014 AAI04015 AAM09569 CAI42256
RNA Seq Atlas 29935

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca