InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: RPA4

Summary

InnateDB Protein

IDBP-79088.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

RPA4

Protein Name

replication protein A4, 30kDa

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000362131

InnateDB Gene

IDBG-79086 (RPA4)

Protein Structure

UniProt Annotation

Function

As part of the alternative replication protein A complex, aRPA, binds single-stranded DNA and probably plays a role in DNA repair. Compared to the RPA2-containing, canonical RPA complex, may not support chromosomal DNA replication and cell cycle progression through S-phase. The aRPA may not promote efficient priming by DNA polymerase alpha but could support DNA polymerase delta synthesis in the presence of PCNA and replication factor C (RFC), the dual incision/excision reaction of nucleotide excision repair and RAD51-dependent strand exchange. {ECO:0000269PubMed:19116208, ECO:0000269PubMed:19942684, ECO:0000269PubMed:19996105, ECO:0000269PubMed:20545304}.

Subcellular Localization

Nucleus {ECO:0000269PubMed:19942684}. Note=Localizes to DNA repair foci after DNA damage.

Disease Associations

Tissue Specificity

Preferentially expressed in placental and colon mucosa. Widely expressed at intermediate or lower levels. {ECO:0000269PubMed:19996105}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 11 experimentally validated interaction(s) in this database.

Experimentally validated
Total	11 [view]
Protein-Protein	10 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003676	nucleic acid binding
GO:0003677	DNA binding
GO:0003697	single-stranded DNA binding

Biological Process

GO:0000077	DNA damage checkpoint
GO:0000082	G1/S transition of mitotic cell cycle
GO:0000278	mitotic cell cycle
GO:0006260	DNA replication
GO:0006270	DNA replication initiation
GO:0006281	DNA repair
GO:0006289	nucleotide-excision repair
GO:0006310	DNA recombination

Cellular Component

GO:0005634	nucleus
GO:0005654	nucleoplasm
GO:0005662	DNA replication factor A complex

Protein Structure and Domains

PDB ID

InterPro

IPR004365 OB-fold nucleic acid binding domain, AA-tRNA synthetase-type
IPR012340 Nucleic acid-binding, OB-fold
IPR014646 Replication factor A protein 2
IPR014892 Replication protein A, C-terminal

PFAM

PF01336
PF08784

PRINTS

PIRSF

PIRSF036949

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q13156