Version 5.4
Homo sapiens Gene: TNMD
Summary
InnateDB Gene IDBG-79122.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol TNMD
Gene Name tenomodulin
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000000005
Encoded Proteins
IDBP-79124
tenomodulin
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a protein that is related to chondromodulin-I, which is a cartilage-specific glycoprotein that functions to stimulate chondrocyte growth and to inhibit tube formation of endothelial cells. This protein is also an angiogenesis inhibitor. Genetic variation in this gene is associated with a risk for type 2 diabetes, central obesity and serum levels of systemic immune mediators in a body size-dependent manner. This gene is also a candidate gene for age-related macular degeneration, though a direct link has yet to be demonstrated. [provided by RefSeq, Sep 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome X:100584802-100599885
Strand Forward strand
Band q22.1
Transcripts
ENST00000373031 ENSP00000362122
ENST00000485971
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0008061 chitin binding
Biological Process
GO:0001886 endothelial cell morphogenesis
GO:0001937 negative regulation of endothelial cell proliferation
GO:0016525 negative regulation of angiogenesis
GO:0035990 tendon cell differentiation
GO:0071773 cellular response to BMP stimulus
Cellular Component
GO:0005635 nuclear envelope
GO:0005737 cytoplasm
GO:0016021 integral component of membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000031250
View Gene Order
ENSBTAG00000021059
Not yet available
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.132957
RefSeq NM_022144 XM_005262176
HUGO
OMIM
CCDS CCDS14469
HPRD 02352
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca