Version 5.4
Homo sapiens Protein: TNMD
Summary
InnateDB Protein IDBP-79124.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol TNMD
Protein Name tenomodulin
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000362122
InnateDB Gene IDBG-79122 (TNMD)
Protein Structure
UniProt Annotation
Function May be an angiogenesis inhibitor.
Subcellular Localization Isoform 1: Membrane {ECO:0000305}; Single- pass type II membrane protein {ECO:0000305}. Nucleus envelope.Isoform 2: Membrane {ECO:0000305}; Single- pass type II membrane protein {ECO:0000305}. Nucleus envelope.Isoform 3: Cytoplasm.
Disease Associations
Tissue Specificity Highly expressed in hypovascular connective tissues such as tendons. Has also strong expression in adipose tissue. {ECO:0000269PubMed:19602561, ECO:0000269PubMed:19780194, ECO:0000269PubMed:22700804}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0008061 chitin binding
Biological Process
GO:0001886 endothelial cell morphogenesis
GO:0001937 negative regulation of endothelial cell proliferation
GO:0016525 negative regulation of angiogenesis
GO:0035990 tendon cell differentiation
GO:0071773 cellular response to BMP stimulus
Cellular Component
GO:0005635 nuclear envelope
GO:0005737 cytoplasm
GO:0016021 integral component of membrane
Protein Structure and Domains
PDB ID
InterPro IPR001002 Chitin-binding, type 1
IPR007084 BRICHOS domain
PFAM PF00187
PF04089
PRINTS PR00451
PIRSF
SMART SM00270
SM01039
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9H2S6
PhosphoSite PhosphoSite-Q9H2S6
TrEMBL
UniProt Splice Variant
Entrez Gene 64102
UniGene Hs.132957
RefSeq NP_071427
HUGO HGNC:17757
OMIM 300459
CCDS CCDS14469
HPRD 02352
IMGT
EMBL AB055421 AF191770 AF234259 AF291656 AL035608 AY358706
GenPept AAG28395 AAG49144 AAK83109 AAQ89069 BAB21756 CAI42846

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca